Over-expression of 5-HT6 Receptor and Activated Jab-1/p-c-Jun Play Important Roles in Pilocarpine-Induced Seizures and Learning-Memory Impairment
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-018-1238-4
Abstract: Cognitive impairment is a common comorbidity in patients with temporal lobe epilepsy (TLE) that severely affects patients’ quality of life. Also, serotonin 5-hydroxytryptamine 6 (5-HT6) receptor plays an important role in cognition. This study aimed… read more here.
Keywords: learning memory; epileptic rats; ht6 receptor;
5-HT6 receptor agonist EMD386088 impairs behavioral flexibility and working memory
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2018.04.032
Abstract: HighlightsEMD386088 treatment impaired probabilistic reversal learning through perseveration.EMD386088 treatment impaired spatial working memory in C57BL/6J mice.Locomotor activity was not altered by systemic EMD386088 treatment. Abstract Serotonin 6 (5‐HT6) receptors are primarily expressed in the central… read more here.
Keywords: emd386088; working memory; memory; ht6 receptor ... See more keywords
Procognitive profiling of a serotonin 5-HT6 receptor antagonist in a complex model system in rats: A novel translational approach for clinical prediction
Sign Up to like & getrecommendations! Published in 2020 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2020.10.014
Abstract: INTRODUCTION The serial clinical failures of novel cognitive enhancer candidates point out the lack of predictive power in the preceding animal experimentation. For a more predictive profiling of putative procognitive drugs in rodents, we recently… read more here.
Keywords: receptor antagonist; system; task; ht6 receptor ... See more keywords
Activation and blockade of basolateral amygdala 5-HT6 receptor produce anxiolytic-like behaviors in an experimental model of Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2018 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2018.05.016
Abstract: &NA; Although the basolateral amygdala (BLA) and serotonin6 (5‐HT6) receptor are involved in modulation of anxiety, their roles in Parkinson' disease (PD)‐related anxiety are still unknown. Thus we perform this study to examine the involvement… read more here.
Keywords: receptor; bla ht6; anxiolytic like; ht6 receptor ... See more keywords
The 5-HT6 receptor interactome: New insight in receptor signaling and its impact on brain physiology and pathologies
Sign Up to like & getrecommendations! Published in 2020 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2019.107839
Abstract: The serotonin (5-HT)6 receptor is a Gs-coupled receptor exclusively expressed in the central nervous system. Highest receptor densities are found in brain regions implicated in mnemonic functions where the receptor is primarily but not exclusively… read more here.
Keywords: receptor interactome; physiology; ht6 receptor; receptor ... See more keywords
The Constitutive Activity of Spinal 5-HT6 Receptors Contributes to Diabetic Neuropathic Pain in Rats
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13020364
Abstract: Diabetic neuropathy is often associated with chronic pain. Serotonin type 6 (5-HT6) receptor ligands, particularly inverse agonists, have strong analgesic potential and may be new candidates for treating diabetic neuropathic pain and associated co-morbid cognitive… read more here.
Keywords: diabetic neuropathic; constitutive activity; neuropathic pain; pain ... See more keywords
Serotonin 5-HT6 Receptor Ligands and Butyrylcholinesterase Inhibitors Displaying Antioxidant Activity—Design, Synthesis and Biological Evaluation of Multifunctional Agents against Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23169443
Abstract: Neurodegeneration leading to Alzheimer’s disease results from a complex interplay of a variety of processes including misfolding and aggregation of amyloid beta and tau proteins, neuroinflammation or oxidative stress. Therefore, to address more than one… read more here.
Keywords: design synthesis; alzheimer disease; activity; ht6 receptor ... See more keywords
New Triazine Derivatives as Serotonin 5-HT6 Receptor Ligands
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28031108
Abstract: Since the number of people with Alzheimer’s disease (AD) continues to rise, new and effective drugs are urgently needed to not only slow down the progression of the disease, but to stop or even prevent… read more here.
Keywords: serotonin ht6; methylpiperazin triazin; triazin amine; ht6 receptor ... See more keywords