Benzoxazolone‐arylpiperazinyl scaffold‐based PET ligand for 5‐HT7: Synthesis and biological evaluation
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21930
Abstract: Efforts are underway to improve the diagnosis and treatment for neurological disorders like depression, anxiety, epilepsy, and schizophrenia. The G‐protein‐coupled receptors (GPCRs) 5‐HT7 receptor, the most recently identified member of 5‐HT receptor family dysregulation has… read more here.
Keywords: ht7; biological evaluation; 11c abo; ligand ... See more keywords
Acupuncture stimulation at HT7 as a non-pharmacological therapy for sleep disorder caused by caffeine administration in rats
Sign Up to like & getrecommendations! Published in 2021 at "Acupuncture in Medicine"
DOI: 10.1177/09645284211011489
Abstract: Objectives: Insomnia is one of the most common sleep disorders and is difficult to completely treat because of the undesirable side effects of hypnotics. The present study was designed to investigate the hypnotic effect of… read more here.
Keywords: acupuncture stimulation; caffeine; stimulation; ht7 ... See more keywords
T Lymphocyte Serotonin 5-HT7 Receptor Is Dysregulated in Natalizumab-Treated Multiple Sclerosis Patients
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DOI: 10.3390/biomedicines10102418
Abstract: Serotonin (5-HT) is known as a potent immune cell modulator in autoimmune diseases and should be protective in the pathogenesis of multiple sclerosis (MS). Nevertheless, there is limited knowledge about receptors involved in 5-HT effects… read more here.
Keywords: natalizumab treated; ht7 receptor; multiple sclerosis; ht7 ... See more keywords
Mitochondrial Membranes of Human SH-SY5Y Neuroblastoma Cells Express Serotonin 5-HT7 Receptor
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DOI: 10.3390/ijms21249629
Abstract: Mitochondria in neurons contribute to energy supply, the regulation of synaptic transmission, Ca2+ homeostasis, neuronal excitability, and stress adaptation. In recent years, several studies have highlighted that the neurotransmitter serotonin (5-HT) plays an important role… read more here.
Keywords: ht7 receptor; mitochondrial membranes; ht7; membranes human ... See more keywords
Therapeutic Potential and Limitation of Serotonin Type 7 Receptor Modulation
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DOI: 10.3390/ijms24032070
Abstract: Although a number of mood-stabilising atypical antipsychotics and antidepressants modulate serotonin type 7 receptor (5-HT7), the detailed contributions of 5-HT7 function to clinical efficacy and pathophysiology have not been fully understood. The mood-stabilising antipsychotic agent,… read more here.
Keywords: serotonin; ht7; modulation; serotonin type ... See more keywords