Cyanobacterial extract with serotonin receptor subtype 7 (5‐HT7R) affinity modulates depression and anxiety‐like behavior in mice
Sign Up to like & getrecommendations! Published in 2018 at "Synapse"
DOI: 10.1002/syn.22059
Abstract: Marine cyanobacteria represent a unique source in the field of drug discovery due to the secondary metabolites they produce and the structural similarity these compounds have to endogenous mammalian receptor ligands. A series of cyanobacteria… read more here.
Keywords: ht7r; affinity; anxiety like; receptor ... See more keywords
In Vitro and In Silico Analysis of the Residence Time of Serotonin 5-HT7 Receptor Ligands with Arylpiperazine Structure: A Structure-Kinetics Relationship Study.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.1c00710
Abstract: During the last decade, the kinetics of drug-target interaction has received increasing attention as an important pharmacological parameter in the drug development process. Several studies have suggested that the lipophilicity of a molecule can play… read more here.
Keywords: ht7 receptor; structure kinetics; structure; ht7r ... See more keywords