NAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2017.11.030
Abstract: HIGHLIGHTSFirst investigation of the role of NMNAT1 in the early stage of tauopathies in mice.htau mice display a robust deficit in food burrowing prior to onset of cognitive symptoms.NMNAT1 overexpression rescues this behavioral abnormality. ABSTRACT… read more here.
Keywords: nad biosynthetic; htau mice; model tauopathy; nmnat1 ... See more keywords
Early Evidence of Low Bone Density and Decreased Serotonergic Synthesis in the Dorsal Raphe of a Tauopathy Model of Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Alzheimer's Disease"
DOI: 10.3233/jad-160658
Abstract: Reduced bone mineral density (BMD) and its clinical sequelae, osteoporosis, occur at a much greater rate in patients with Alzheimer’s disease (AD), often emerging early in the disease before significant cognitive decline is seen. Reduced… read more here.
Keywords: alzheimer disease; density; bone; dorsal raphe ... See more keywords
SMaRT modulation of tau isoforms rescues cognitive and motor impairments in a preclinical model of tauopathy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.951384
Abstract: Tau is a microtubule-associated protein predominantly expressed in neurons, which participates in microtubule polymerization and axonal transport. Abnormal tau metabolism leads to neurodegenerative diseases named tauopathies, such as Alzheimer’s disease and frontotemporal dementia. The alternative… read more here.
Keywords: tau; modulation; htau mice; motor ... See more keywords