Telomerase reverse transcriptase germline mutations and hepatocellular carcinoma in patients with nonalcoholic fatty liver disease
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Medicine"
DOI: 10.1002/cam4.1078
Abstract: In an increasing proportion of cases, hepatocellular carcinoma (HCC) develops in patients with nonalcoholic fatty liver disease (NAFLD). Mutations in telomerase reverse transcriptase (hTERT) are associated with familial liver diseases. The aim of this study… read more here.
Keywords: liver disease; htert; nafld hcc; liver ... See more keywords
Telomerase activity, TERT expression, hTERT promoter alterations, and alternative lengthening of the telomeres (ALT) in meningiomas – a systematic review
Sign Up to like & getrecommendations! Published in 2019 at "Neurosurgical Review"
DOI: 10.1007/s10143-019-01087-3
Abstract: Telomerase activity and (human) Telomerase Reverse Transcriptase (hTERT) expression are considered hallmarks in oncogenesis of neoplasms and are upregulated by alterations of the hTERT promoter. In meningiomas, numerous studies investigated hTERT expression, telomerase activity, promoter… read more here.
Keywords: telomerase; telomerase activity; expression; htert ... See more keywords
Cultured human amniocytes express hTERT, which is distributed between nucleus and cytoplasm and is secreted in extracellular vesicles.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2016.12.077
Abstract: BACKGROUND An increasing number of studies on stem cells suggests that the therapeutic effect they exert is primarily mediated by a paracrine regulation through extracellular vesicles (EVs) giving solid grounds for stem cell EVs to… read more here.
Keywords: extracellular vesicles; cultured human; express htert; amniocytes express ... See more keywords
KLF4 signalling in carcinogenesis and epigenetic regulation of hTERT.
Sign Up to like & getrecommendations! Published in 2018 at "Medical hypotheses"
DOI: 10.1016/j.mehy.2018.03.012
Abstract: Gene expression is crucial and tightly regulated to steer the development, differentiation, proliferation and even apoptosis of a cell. Each cell and tissue type shows a unique repertoire of transcription factors. Tissue micro-environmental regulation of… read more here.
Keywords: klf4; expression; htert; carcinogenesis ... See more keywords
CDK1 dependent phosphorylation of hTERT contributes to cancer progression
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DOI: 10.1038/s41467-020-15289-7
Abstract: The telomerase reverse transcriptase is upregulated in the majority of human cancers and contributes directly to cell transformation. Here we report that hTERT is phosphorylated at threonine 249 during mitosis by the serine/threonine kinase CDK1.… read more here.
Keywords: phosphorylation htert; threonine 249; htert; cancer ... See more keywords
Genome-wide screens identify specific drivers of mutant hTERT promoters
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2105171119
Abstract: Significance Mutations in hTERT promoter are seen in over 19% of human cancers, irrespective of the cancer type. Understanding the molecular players that regulate Mut-hTERT promoters may help the design of effective targeting strategies to… read more here.
Keywords: htert promoters; genome wide; mut htert; htert ... See more keywords
The prognostic significance of hTERT overexpression in cancers
Sign Up to like & getrecommendations! Published in 2018 at "Medicine"
DOI: 10.1097/md.0000000000011794
Abstract: Background: Human telomerase reverse transcriptase (hTERT) plays an important role in cancer progression. Recently, several clinical studies investigated how the overexpression of hTERT predicts the poor prognosis of solid tumors. However, the results were inconclusive,… read more here.
Keywords: overexpression; overexpression htert; htert; significance htert ... See more keywords
Aberrant hTERT promoter methylation predicts prognosis in Chinese patients with acral and mucosal melanoma
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DOI: 10.1097/md.0000000000017578
Abstract: Abstract Background: To evaluate the methylation levels of human telomerase reverse transcriptase (hTERT) promoter three CpG island (CGIs) regions and its prognostic impact in Chinese patients with acral and mucosal melanoma. Methods: Bioinformatics software was… read more here.
Keywords: htert; level; mucosal melanoma; melanoma ... See more keywords
Telomerase reverse transcriptase coordinates with the epithelial-to-mesenchymal transition through a feedback loop to define properties of breast cancer stem cells
Sign Up to like & getrecommendations! Published in 2018 at "Biology Open"
DOI: 10.1242/bio.034181
Abstract: ABSTRACT Telomerase and its core component, telomerase reverse transcriptase (hTERT), are critical for stem cell compartment integrity. Normal adult stem cells have the longest telomeres in a given tissue, a property mediated by high hTERT… read more here.
Keywords: cscs; expression; htert; cancer ... See more keywords
MicroRNA-532 and microRNA-3064 inhibit cell proliferation and invasion by acting as direct regulators of human telomerase reverse transcriptase in ovarian cancer
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DOI: 10.1371/journal.pone.0173912
Abstract: Human telomerase reverse transcriptase (hTERT) plays a crucial role in ovarian cancer (OC) progression. However, the mechanisms underlying hTERT upregulation in OC, and the specific microRNAs (miRNAs) involved in the regulation of hTERT in OC… read more here.
Keywords: proliferation; htert; 532 mir; mir 532 ... See more keywords
Immortalization of common marmoset monkey fibroblasts by piggyBac transposition of hTERT
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0204580
Abstract: Following a certain type-specific number of mitotic divisions, terminally differentiated cells undergo proliferative senescence, thwarting efforts to expand different cell populations in vitro for the needs of scientific research or medical therapies. The primary cause… read more here.
Keywords: immortalization common; htert; marmoset; common marmoset ... See more keywords