Genome-wide screens identify specific drivers of mutant hTERT promoters
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2105171119
Abstract: Significance Mutations in hTERT promoter are seen in over 19% of human cancers, irrespective of the cancer type. Understanding the molecular players that regulate Mut-hTERT promoters may help the design of effective targeting strategies to… read more here.
Keywords: htert promoters; genome wide; mut htert; htert ... See more keywords
Telomerase promoter mutations and copy number alterations in solitary fibrous tumours
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Pathology"
DOI: 10.1136/jclinpath-2018-205132
Abstract: Aims Solitary fibrous tumour (SFT) is an infrequently metastasising mesenchymal tumour defined by the NAB2–STAT6 fusion gene. Activating mutations in the telomerase reverse transcriptase (hTERT) gene promoter has been reported to associate with adverse patient… read more here.
Keywords: copy number; solitary fibrous; promoter mutations; promoter ... See more keywords