ISSLS prize in basic science 2021: a novel inducible system to regulate transgene expression of TIMP1
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DOI: 10.1007/s00586-021-06728-0
Abstract: Inflammatory and oxidative stress upregulates matrix metalloproteinase (MMP) activity, leading to intervertebral disc degeneration (IDD). Gene therapy using human tissue inhibitor of metalloproteinase 1 (hTIMP1) has effectively treated IDD in animal models. However, persistent unregulated… read more here.
Keywords: transgene expression; htimp1 cells; aav htimp1; htimp1 ... See more keywords