HTLV infected individuals have increased B-cell activation and proinflammatory regulatory T-cells.
Sign Up to like & getrecommendations! Published in 2019 at "Immunobiology"
DOI: 10.1016/j.imbio.2019.11.013
Abstract: Human T-lymphotropic virus (HTLV) affects the human immune system in many ways, most notably by inducing proliferation of infected CD4 + T cells, but several other cell types are also affected. To characterize the effects of HTLV… read more here.
Keywords: infected individuals; htlv infected; regulatory cells; activation ... See more keywords
Impaired TNF, IL-1β, and IL-17 production and increased susceptibility to Mycobacterium tuberculosis infection in HTLV-1 infected individuals.
Sign Up to like & getrecommendations! Published in 2018 at "Tuberculosis"
DOI: 10.1016/j.tube.2017.10.004
Abstract: IFN-γ and TNF play critical roles in the control of Mycobacterium tuberculosis infection. Despite leading to an exaggerated production of inflammatory cytokines, HTLV-1 infection increases the risk of developing tuberculosis (TB). However, the immune mechanisms… read more here.
Keywords: infected individuals; production; htlv infected; infection ... See more keywords
Polymorphisms in HLA-C and KIR alleles are not associated with HAM/TSP risk in HTLV-1-infected subjects.
Sign Up to like & getrecommendations! Published in 2018 at "Virus research"
DOI: 10.1016/j.virusres.2017.11.010
Abstract: INTRODUCTION Several genetic polymorphisms may be related to susceptibility or resistance to viral disease outcomes. Immunological or genetic factors may act as major triggers of the immune pathogenesis of HAM/TSP. This study investigated the association… read more here.
Keywords: ham; htlv infected; ham tsp; hla kir ... See more keywords
Dissecting Multicellular Ecosystems of HTLV-1 Infection and ATL By Multi-Omics Single Cell Analysis
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood-2020-141755
Abstract: Adult T-cell leukemia/lymphoma (ATL) is an aggressive peripheral T-cell malignancy, caused by human T-cell leukemia virus type-1 (HTLV-1) infection. To elucidate immune microenvironment and heterogeneity of HTLV-1-infected normal and leukemic cells, we performed multi-omics single… read more here.
Keywords: research; htlv infected; analysis; research funding ... See more keywords
Activation of PERK-ATF4-CHOP pathway as a novel therapeutic approach for efficient elimination of HTLV-1-infected cells.
Sign Up to like & getrecommendations! Published in 2020 at "Blood advances"
DOI: 10.1182/bloodadvances.2019001139
Abstract: Patients with adult T-cell leukemia (ATL) exhibit a poor prognosis and overall survival rate when treated with standard chemotherapy, highlighting the continued requirement for the development of novel safe and effective therapies for human T-cell… read more here.
Keywords: htlv; chop; htlv infected; activation ... See more keywords
MAIT cells are reduced in frequency and functionally impaired in human T lymphotropic virus type 1 infection: Potential clinical implications
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0175345
Abstract: HTLV-1 infection is associated with several inflammatory disorders, including the neurodegenerative condition HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). It is unclear why a minority of infected subjects develop HAM/TSP. The cellular immune response has been implicated… read more here.
Keywords: frequency; mait cells; htlv infected; infection ... See more keywords
Prevalence of Bowel Symptoms in Patients Infected with Human T-Lymphotropic type 1 Virus.
Sign Up to like & getrecommendations! Published in 2019 at "Revista da Sociedade Brasileira de Medicina Tropical"
DOI: 10.1590/0037-8682-0486-2018
Abstract: INTRODUCTION Bowel dysfunction is frequent in patients with spinal cord diseases, but little is known about the prevalence of bowel symptoms in human T-lymphotropic virus-(HTLV-1) infected individuals. The purpose of this study is to determine… read more here.
Keywords: bowel; bowel symptoms; prevalence bowel; htlv infected ... See more keywords
Hypovitaminosis D Is Associated with Higher Levels of Inflammatory Cytokines and with HAM/TSP in HTLV-Infected Patients
Sign Up to like & getrecommendations! Published in 2021 at "Viruses"
DOI: 10.3390/v13112223
Abstract: Recent studies have shown the effects of vitamin D on host response to infectious diseases. Some studies detected a high prevalence of hypovitaminosis D in HIV-infected patients, but scarce information exists for HTLV-1 infection. We… read more here.
Keywords: htlv; higher levels; htlv infected; ham tsp ... See more keywords
Postural Adjustments in HTLV-1 Infected Patients during a Self-Initiated Perturbation
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14112389
Abstract: Background: Human T-cell lymphotropic virus type 1 (HTLV-1) infection can be associated with tropical spastic paraparesis (TSP/HAM), which causes neurological myelopathy and sensory and muscle tone alterations, leading to gait and balance impairments. Once trunk… read more here.
Keywords: htlv infected; control; postural adjustments; infected patients ... See more keywords
Evaluation of the effects of 1,25VitD3 on Th17 cells and Tregs in HTLV-1 infected cell lines.
Sign Up to like & getrecommendations! Published in 2022 at "Acta virologica"
DOI: 10.4149/av_2022_202
Abstract: Human T-lymphotropic virus type 1 (HTLV-1) causes chronic infections of human T lymphocytes. The present study aimed to evaluate the effects of 1,25VitD3 on the proportion of Tregs and Th17 cells, the expression of related… read more here.
Keywords: th17 cells; htlv infected; effects 25vitd3; infected cell ... See more keywords