Application of HTLV-1 tax transgenic mice for therapeutic intervention.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in biological regulation"
DOI: 10.1016/j.jbior.2018.02.004
Abstract: Adult T-cell leukemia-lymphoma (ATL) is a refractory T-cell malignancy caused by infection of human T-cell leukemia virus type I (HTLV-I). Although the pathogenesis of ATL remains unclear, HTLV-1 oncoprotein Tax plays an important role in… read more here.
Keywords: tax; tax transgenic; transgenic mice; mice ... See more keywords
Diversity of HLA-A2-Restricted and Immunodominant Epitope Repertoire of Human T-Lymphotropic Virus Type 1 (HTLV-1) Tax Protein: Novel Insights among N-Terminal, Central and C-Terminal Regions
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13030545
Abstract: The present study sought to search for the immunodominance related to the N-terminal, Central and C-terminal regions of HTLV-1 Tax using novel, cutting-edge peptide microarray analysis. In addition, in silico predictions were performed to verify… read more here.
Keywords: htlv tax; hla; terminal regions; tax ... See more keywords
Mechanisms of Oncogenesis by HTLV-1 Tax
Sign Up to like & getrecommendations! Published in 2020 at "Pathogens"
DOI: 10.3390/pathogens9070543
Abstract: The human T-cell lymphotropic virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia/lymphoma (ATLL), a neoplasm of CD4+CD25+ T cells that occurs in 2–5% of infected individuals after decades of asymptomatic latent… read more here.
Keywords: htlv; tax; mechanisms oncogenesis; oncogenesis htlv ... See more keywords