1H NMR based pharmacometabolomics analysis of urine identifies metabolic phenotype of clopidogrel high on treatment platelets reactivity in coronary artery disease patients
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2017.08.018
Abstract: HIGHLIGHTSWe analysed patients’ urine samples before and after the administration of 600 mg clopidogrel loading dose using 1H NMR.Multivariate analysis identified metabotypes associated with clopidogrel high on treatment platelets reactivity (HTPR).Urinary metabotypes revealed that clopidogrel… read more here.
Keywords: associated clopidogrel; clopidogrel high; clopidogrel htpr; clopidogrel ... See more keywords
Impact of high on-treatment platelet reactivity after angioplasty in patients with critical limb ischemia.
Sign Up to like & getrecommendations! Published in 2021 at "Vascular pharmacology"
DOI: 10.1016/j.vph.2021.106925
Abstract: OBJECTIVES Dual antiplatelet therapy (DAPT) with aspirin and clopidogrel is standard of care in patients with peripheral artery disease (PAD) after percutaneous transluminal angioplasty (PTA). However, high on treatment platelet reactivity (HTPR) to DAPT is… read more here.
Keywords: patients critical; high treatment; limb; htpr ... See more keywords
The association between high on-treatment platelet reactivity and early recurrence of ischemic events after minor stroke or TIA
Sign Up to like & getrecommendations! Published in 2017 at "Neurological Research"
DOI: 10.1080/01616412.2017.1312793
Abstract: Abstract Objectives: To evaluate the role of HTPR in predicting early recurrence of ischemic events in patients with minor ischemic stroke or high-risk TIA. Methods: From January 2014 to September 2014, a single center continuously… read more here.
Keywords: recurrence ischemic; early recurrence; stroke tia; htpr ... See more keywords
Association of clopidogrel high on-treatment reactivity with clinical outcomes and gene polymorphism in acute ischemic stroke patients
Sign Up to like & getrecommendations! Published in 2020 at "Medicine"
DOI: 10.1097/md.0000000000019472
Abstract: Abstract High on-treatment platelet reactivity (HTPR) was suggested to be better correlated with recurrent ischemic events as compared with gene polymorphism, whereas most of the results were from white populations with acute coronary disease. The… read more here.
Keywords: ischemic stroke; gene polymorphism; stroke; high treatment ... See more keywords
Should CYP2C19 Genotyping Be Recommended as a Straight Forward Approach to Optimize Clopidogrel Utilization in Patients with Ischemic Stroke Complicated by Type 2 Diabetes Mellitus?
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacogenomics and Personalized Medicine"
DOI: 10.2147/pgpm.s279719
Abstract: Background There have been few studies on CYP2C19 genotypes and clopidogrel response associated with ischemic stroke (IS), especially IS complicated by type 2 diabetes mellitus (T2DM). This study aimed to investigate the possible association between… read more here.
Keywords: ischemic stroke; complicated type; diabetes mellitus; type diabetes ... See more keywords