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   Articles with "htr svneo" as a keyword



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Long noncoding RNA PVT1 accelerates the growth of placental trophoblasts in preeclampsia through the microRNA‐24‐3p/HSD11B2 axis

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recommendations! Published in 2022 at "Molecular Reproduction and Development"

DOI: 10.1002/mrd.23575

Abstract: Long noncoding RNA plasmacytoma variant translocation 1 (PVT1) is essential for the maintenance of normal functions of trophoblasts in preeclampsia (PE). This study aims to decipher the concrete mechanism of PVT1 with the microRNA‐24‐3p/Type‐2 11β‐hydroxysteroid… read more here.

Keywords: hsd11b2; htr svneo; growth; pvt1 ... See more keywords
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Effect and mechanism of microRNA‐515‐5p in proliferation and apoptosis of trophoblast cells in preeclampsia via manipulating histone deacetylase 2

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recommendations! Published in 2022 at "Molecular Reproduction and Development"

DOI: 10.1002/mrd.23649

Abstract: Preeclampsia (PE) refers to a pregnancy‐specific disease that begins with the placenta. Differentially expressed microRNAs (miRs) are a feature of PE. This study tried to elicit the functional mechanism of miR‐515‐5p in trophoblast cell behaviors… read more here.

Keywords: htr svneo; proliferation apoptosis; svneo cells; mir 515 ... See more keywords
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Cadmium cytotoxicity and possible mechanisms in human trophoblast HTR‐8/SVneo cells

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recommendations! Published in 2021 at "Environmental Toxicology"

DOI: 10.1002/tox.23110

Abstract: The accumulation of cadmium (Cd) in the human body through food chain can lead to adverse pregnancy outcomes. In this study, Cd cytotoxicity and its mechanisms in HTR‐8/SVneo cells were investigated. Cd disrupted the cellular… read more here.

Keywords: htr svneo; cytotoxicity possible; possible mechanisms; svneo cells ... See more keywords
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Cannabidiol disrupts apoptosis, autophagy and invasion processes of placental trophoblasts.

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recommendations! Published in 2021 at "Archives of toxicology"

DOI: 10.1007/s00204-021-03122-z

Abstract: Cannabidiol (CBD) is a constituent of Cannabis sativa without psychotropic activity, whose medical benefits have been recognised. However, little is known about the potential toxic effects of CBD on reproductive health. Placental development involves tightly… read more here.

Keywords: cannabidiol disrupts; htr svneo; invasion; apoptosis autophagy ... See more keywords
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Methylmercury cytotoxicity and possible mechanisms in human trophoblastic HTR-8/SVneo cells.

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recommendations! Published in 2021 at "Ecotoxicology and environmental safety"

DOI: 10.1016/j.ecoenv.2020.111520

Abstract: Methylmercury (MeHg) exposure during pregnancy can lead to adverse outcomes, including miscarriage and intrauterine growth retardation. In this study, MeHg cytotoxicity and its mechanisms in HTR-8/SVneo cells were investigated. MeHg inhibited HTR-8/SVneo cell viability and… read more here.

Keywords: svneo cells; cytotoxicity; htr svneo; mehg ... See more keywords

Involvement of mTOR, JNK and PI3K in the negative effect of ethanol and metformin on the human first‐trimester extravillous trophoblast HTR‐8/SVneo cell line

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recommendations! Published in 2018 at "European Journal of Pharmacology"

DOI: 10.1016/j.ejphar.2018.05.038

Abstract: Abstract Our aim was to investigate the effect of two xenobiotics to which pregnant woman may be exposed, the drug of abuse ethanol (EtOH) (and its metabolite acetaldehyde (ACA)) and the therapeutic agent metformin (METF),… read more here.

Keywords: metf; jnk pi3k; htr svneo; mtor jnk ... See more keywords
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Immunoglobulins from sera of antiphospholipid syndrome patients are internalized in the HTR-8/SVneo cell line and cytotrophoblast in culture.

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recommendations! Published in 2018 at "Immunobiology"

DOI: 10.1016/j.imbio.2018.06.002

Abstract: Women with antiphospholipid syndrome (APS) experience pregnancy complications mostly due to impaired trophoblast cell functions. Antiphospholipid antibodies (aPL) affect extravillous trophoblast in vivo and in culture, but the mechanisms are still poorly understood. Previously, syncytiotrophoblast… read more here.

Keywords: cell line; culture; htr svneo; antiphospholipid syndrome ... See more keywords
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Tumor necrosis factor‐alpha suppresses the invasion of HTR‐8/SVneo trophoblast cells through microRNA‐145‐5p‐mediated downregulation of Cyr61

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recommendations! Published in 2018 at "Life Sciences"

DOI: 10.1016/j.lfs.2018.08.005

Abstract: ABSTRACT Deficiency in trophoblast invasion is causally linked to the pathogenesis of preeclampsia. Tumor necrosis factor‐alpha (TNF‐&agr;) shows the ability to suppress the invasiveness of trophoblasts, while cysteine‐rich 61 (Cyr61) exerts an opposite function in… read more here.

Keywords: htr svneo; invasion; tnf agr; trophoblast ... See more keywords

HTR-8/SVneo: A model for epithelial to mesenchymal transition in the human placenta.

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recommendations! Published in 2020 at "Placenta"

DOI: 10.1016/j.placenta.2019.12.013

Abstract: INTRODUCTION The placenta is a transitory organ essential for proper fetal maturation and growth. Trophoblasts, the main cell type of the placenta, differentiate along the villous or extravillous pathways. The ability of villous cytotrophoblasts to… read more here.

Keywords: htr svneo; svneo; transition; placenta ... See more keywords
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Toxicity assessments of selected trichloroethylene and perchloroethylene metabolites in three in vitro human placental models.

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recommendations! Published in 2022 at "Reproductive toxicology"

DOI: 10.1016/j.reprotox.2022.03.003

Abstract: Residential and occupational exposures to the industrial solvents perchloroethylene (PERC) and trichloroethylene (TCE) present public health concerns. In humans, maternal PERC and TCE exposures can be associated with adverse birth outcomes. Because PERC and TCE… read more here.

Keywords: caspase activity; perc tce; three vitro; htr svneo ... See more keywords
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EGF-mediated reduced miR-92a-1-5p controls HTR-8/SVneo cell invasion through activation of MAPK8 and FAS which in turn increase MMP-2/-9 expression

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recommendations! Published in 2020 at "Scientific Reports"

DOI: 10.1038/s41598-020-68966-4

Abstract: The members of human miR-17-92 cluster are implicated in several cancers and are known to increase cancer cells invasiveness. The present study reports reduced expression of miR-92a-1-5p in EGF treated HTR-8/SVneo trophoblastic cells by NGS… read more here.

Keywords: egf mediated; htr svneo; expression; mir 92a ... See more keywords