Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A Genotypes and Serotonin Reuptake Inhibitor Antidepressants.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2903
Abstract: Serotonin reuptake inhibitor antidepressants, including selective serotonin reuptake inhibitors (SSRIs; i.e., citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline), serotonin and norepinephrine reuptake inhibitors (SNRIs; i.e., desvenlafaxine, duloxetine, levomilnacipran, milnacipran, and venlafaxine), and serotonin modulators with… read more here.
Keywords: htr2a; cyp2d6 cyp2c19; cyp2c19; cyp2c19 cyp2b6 ... See more keywords
Stress exposure and psychopathology alter methylation of the serotonin receptor 2A (HTR2A) gene in preschoolers
Sign Up to like & getrecommendations! Published in 2017 at "Development and Psychopathology"
DOI: 10.1017/s0954579417001274
Abstract: Abstract Serotonin signaling pathways play a key role in brain development, stress reactivity, and mental health. Epigenetic alterations in the serotonin system may underlie the effect of early life stress on psychopathology. The current study… read more here.
Keywords: methylation; serotonin; stress exposure; psychopathology ... See more keywords
In vitro monitoring of HTR2A-positive neurons derived from human-induced pluripotent stem cells
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-95041-3
Abstract: The serotonin 5-HT2A receptor (5-HT2AR) has been receiving increasing attention because its genetic variants have been associated with a variety of neurological diseases. To elucidate the pathogenesis of the neurological diseases associated with 5-HT2AR gene… read more here.
Keywords: positive neurons; human induced; pluripotent stem; induced pluripotent ... See more keywords
Circulating methylation level of HTR2A is associated with inflammation and disease activity in rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1054451
Abstract: Objectives HTR2A is previously identified as a susceptibility gene for rheumatoid arthritis (RA). In this study, we performed the association analysis between DNA methylation of HTR2A with RA within peripheral blood samples. Methods We enrolled… read more here.
Keywords: methylation; disease; rheumatoid arthritis; htr2a ... See more keywords