The multifaced role of HtrA1 in the development of joint and skeletal disorders.
Sign Up to like & getrecommendations! Published in 2022 at "Bone"
DOI: 10.1016/j.bone.2022.116350
Abstract: HtrA1 (High temperature requirement A1) family proteins include four members, widely conserved from prokaryotes to eukaryotes, named HtrA1, HtrA2, HtrA3 and HtrA4. HtrA1 is a serine protease involved in a variety of biological functions regulating… read more here.
Keywords: htra1; skeletal disorders; role htra1; role ... See more keywords
Second and third trimester serum levels of HtrA1 in pregnancies affected by pre-eclampsia.
Sign Up to like & getrecommendations! Published in 2021 at "Placenta"
DOI: 10.1016/j.placenta.2021.02.003
Abstract: INTRODUCTION Altered placental expression of high temperature requirement factor A1 (HtrA1) is implicated in abnormal trophoblastic invasion and endothelial dysfunction in pre-eclampsia (PE). Serum levels of HtrA1 have been proposed as a novel biomarker to… read more here.
Keywords: htra1; serum htra1; serum; htra1 levels ... See more keywords
Inactivation of the serine protease HTRA1 inhibits tumor growth by deregulating angiogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-018-0258-4
Abstract: The serine protease HTRA1 is involved in several vascular diseases and its expression is often deregulated in cancer. We aimed at identifying how HTRA1 in the vasculature affects tumor growth. Here we report that silencing… read more here.
Keywords: angiogenesis; htra1; serine protease; protease htra1 ... See more keywords
Heterozygous HTRA1 Mutations Cause Cerebral Small Vessel Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Neurology: Genetics"
DOI: 10.1212/nxg.0000000000200044
Abstract: Background and Objectives Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) is a rare hereditary cerebrovascular disease caused by homozygous or compound heterozygous variations in the high-temperature requirement A serine peptidase 1 (HTRA1)… read more here.
Keywords: cause cerebral; heterozygous htra1; htra1; htra1 mutations ... See more keywords
Serine Protease HTRA1 as a Novel Target Antigen in Primary Membranous Nephropathy.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2020101395
Abstract: BACKGROUND Identification of target antigens PLA2R, THSD7A, NELL1, or Semaphorin-3B can explain the majority of cases of primary membranous nephropathy (MN). However, target antigens remain unidentified in 15%-20% of patients. METHODS A multipronged approach, using… read more here.
Keywords: serine protease; target; htra1; protease htra1 ... See more keywords
HTRA1 in Placental Cell Models: A Possible Role in Preeclampsia
Sign Up to like & getrecommendations! Published in 2023 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb45050246
Abstract: The HtrA serine peptidase 1 (HTRA1) is a multidomain secretory protein with serine–protease activity involved in the regulation of many cellular processes in both physiological and pathological conditions. HTRA1 is normally expressed in the human… read more here.
Keywords: cell; role; htra1; serine protease ... See more keywords
HtrA1 in Gestational Diabetes Mellitus: A Possible Biomarker?
Sign Up to like & getrecommendations! Published in 2022 at "Diagnostics"
DOI: 10.3390/diagnostics12112705
Abstract: Background: The high-temperature requirement A 1 (HtrA1) is a multidomain secretory protein with serine-protease activity, expressed in many tissues, including placenta, where its expression is higher in the first trimester, suggesting an association of this… read more here.
Keywords: htra1; trimester; third trimester; first trimester ... See more keywords
HTRA1 Regulates Subclinical Inflammation and Activates Proangiogenic Response in the Retina and Choroid
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231810206
Abstract: High-temperature requirement A1 (HtrA1) has been identified as a disease-susceptibility gene for age-related macular degeneration (AMD) including polypoidal choroidal neovasculopathy (PCV). We characterized the underlying phenotypic changes of transgenic (Tg) mice expressing ubiquitous CAG promoter… read more here.
Keywords: htra1; subclinical inflammation; cag htra1; mice ... See more keywords
TGF-β/Smad Signalling Activation by HTRA1 Regulates the Function of Human Lens Epithelial Cells and Its Mechanism in Posterior Subcapsular Congenital Cataract
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232214431
Abstract: Congenital cataract is the leading cause of blindness among children worldwide. Patients with posterior subcapsular congenital cataract (PSC) in the central visual axis can result in worsening vision and stimulus deprivation amblyopia. However, the pathogenesis… read more here.
Keywords: congenital cataract; htra1; lens epithelial; tgf smad ... See more keywords
HTRA1 Variants and the Interaction with Smoking Confer the Genetic Susceptibility to Ischemic Stroke
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Medical Sciences"
DOI: 10.7150/ijms.45856
Abstract: High temperature requirement protein A1 (HtrA1) was identified as the causative gene of autosomal recessive arteriopathy and associated with lacunar ischemic stroke (IS) in European. This study aimed at evaluating the association of HTRA1 with… read more here.
Keywords: ischemic stroke; htra1; genetic susceptibility; smoking ... See more keywords