Widening the Spectrum of Fusion Events in Schwannoma: Identification of a Novel TANC1::HTRA1 Fusion
Sign Up to like & getrecommendations! Published in 2025 at "Genes"
DOI: 10.1002/gcc.70072
Abstract: A range of genomic drivers have been identified in schwannomas, including a number of translocations, most commonly SH3PXD2A::HTRA1. To date, despite the analysis of large numbers of cases, no examples of variant HTRA1 partners have… read more here.
Keywords: tanc1 htra1; fusion; novel tanc1; htra1 ... See more keywords
Downregulation of HTRA1 Promotes EMT and Anoikis Resistance in Colorectal Cancer via Activation of Hippo/YAP1 Pathway by Facilitating LATS2 Degradation
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23933
Abstract: Epithelial‐mesenchymal transition (EMT) and anoikis resistance are crucial characteristics for tumor cell metastasis. High‐temperature requirement A1 (HTRA1) has been identified as a serine protease with chaperone functions, but its role in the regulation of EMT,… read more here.
Keywords: emt anoikis; anoikis resistance; yap1; hippo ... See more keywords
The multifaced role of HtrA1 in the development of joint and skeletal disorders.
Sign Up to like & getrecommendations! Published in 2022 at "Bone"
DOI: 10.1016/j.bone.2022.116350
Abstract: HtrA1 (High temperature requirement A1) family proteins include four members, widely conserved from prokaryotes to eukaryotes, named HtrA1, HtrA2, HtrA3 and HtrA4. HtrA1 is a serine protease involved in a variety of biological functions regulating… read more here.
Keywords: htra1; skeletal disorders; role htra1; role ... See more keywords
Second and third trimester serum levels of HtrA1 in pregnancies affected by pre-eclampsia.
Sign Up to like & getrecommendations! Published in 2021 at "Placenta"
DOI: 10.1016/j.placenta.2021.02.003
Abstract: INTRODUCTION Altered placental expression of high temperature requirement factor A1 (HtrA1) is implicated in abnormal trophoblastic invasion and endothelial dysfunction in pre-eclampsia (PE). Serum levels of HtrA1 have been proposed as a novel biomarker to… read more here.
Keywords: htra1; serum htra1; serum; htra1 levels ... See more keywords
Inactivation of the serine protease HTRA1 inhibits tumor growth by deregulating angiogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-018-0258-4
Abstract: The serine protease HTRA1 is involved in several vascular diseases and its expression is often deregulated in cancer. We aimed at identifying how HTRA1 in the vasculature affects tumor growth. Here we report that silencing… read more here.
Keywords: angiogenesis; htra1; serine protease; protease htra1 ... See more keywords
Carfilzomib relieves pancreatitis-initiated pancreatic ductal adenocarcinoma by inhibiting high-temperature requirement protein A1
Sign Up to like & getrecommendations! Published in 2024 at "Cell Death Discovery"
DOI: 10.1038/s41420-024-01806-w
Abstract: Pancreatitis is a crucial risk factor for pancreatic ductal adenocarcinoma (PDAC), and our previous study had proved high-temperature requirement protein A1 (HTRA1) exacerbates pancreatitis insult; however, the function and mechanism of HTRA1 in pancreatitis-initiated PDAC… read more here.
Keywords: pancreatitis initiated; protein; htra1; carfilzomib ... See more keywords
HTRA1 disaggregates α-synuclein amyloid fibrils and converts them into non-toxic and seeding incompetent species
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-46538-8
Abstract: Parkinson’s disease (PD) is closely linked to α-synuclein (α-syn) misfolding and accumulation in Lewy bodies. The PDZ serine protease HTRA1 degrades fibrillar tau, which is associated with Alzheimer’s disease, and inactivating mutations to mitochondrial HTRA2… read more here.
Keywords: synuclein amyloid; disaggregates synuclein; syn fibrils; htra1 ... See more keywords
Inhibition of the serine protease HtrA1 by SerpinE2 suggests an extracellular proteolytic pathway in the control of neural crest migration
Sign Up to like & getrecommendations! Published in 2024 at "eLife"
DOI: 10.1101/2023.09.05.556243
Abstract: We previously showed that SerpinE2 and the serine protease HtrA1 modulate fibroblast growth factor (FGF) signaling in germ layer specification and head-to-tail development of Xenopus embryos. Here we present an extracellular proteolytic mechanism involving this… read more here.
Keywords: migration; serine protease; htra1; protease htra1 ... See more keywords
Heterozygous HTRA1 Mutations Cause Cerebral Small Vessel Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Neurology: Genetics"
DOI: 10.1212/nxg.0000000000200044
Abstract: Background and Objectives Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) is a rare hereditary cerebrovascular disease caused by homozygous or compound heterozygous variations in the high-temperature requirement A serine peptidase 1 (HTRA1)… read more here.
Keywords: cause cerebral; heterozygous htra1; htra1; htra1 mutations ... See more keywords
Serine Protease HTRA1 as a Novel Target Antigen in Primary Membranous Nephropathy.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2020101395
Abstract: BACKGROUND Identification of target antigens PLA2R, THSD7A, NELL1, or Semaphorin-3B can explain the majority of cases of primary membranous nephropathy (MN). However, target antigens remain unidentified in 15%-20% of patients. METHODS A multipronged approach, using… read more here.
Keywords: serine protease; target; htra1; protease htra1 ... See more keywords
HTRA1 in Placental Cell Models: A Possible Role in Preeclampsia
Sign Up to like & getrecommendations! Published in 2023 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb45050246
Abstract: The HtrA serine peptidase 1 (HTRA1) is a multidomain secretory protein with serine–protease activity involved in the regulation of many cellular processes in both physiological and pathological conditions. HTRA1 is normally expressed in the human… read more here.
Keywords: cell; role; htra1; serine protease ... See more keywords