A new function for the serine protease HtrA2 in controlling radiation‐induced senescence in cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13187
Abstract: Radiation therapy can induce cellular senescence in cancer cells, leading to short‐term tumor growth arrest but increased long‐term recurrence. To better understand the molecular mechanisms involved, we developed a model of radiation‐induced senescence in cultured… read more here.
Keywords: htra2; senescence; radiation; radiation induced ... See more keywords
mRNA microarray profiling identifies a novel circulating HTRA2 for detection of gastric cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of clinical laboratory analysis"
DOI: 10.1002/jcla.24054
Abstract: BACKGROUND mRNAs have been shown to be critical biomarkers or therapeutic targets for human diseases. However, only a few of them have been studied as blood-based biomarkers for gastric carcinoma (GC) detection. METHODS mRNA expression… read more here.
Keywords: detection; htra2; mrna microarray; expression ... See more keywords
Structural basis of protein substrate processing by human mitochondrial high-temperature requirement A2 protease
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2203172119
Abstract: Significance Protein aggregates are often toxic, leading to impaired cellular activities and disease. The human HtrA2 trimeric enzyme cleaves such aggregates, and mutations in HtrA2 are causative for various neurodegenerative disorders, such as Parkinson’s disease… read more here.
Keywords: htra2; structural basis; protein substrate; basis protein ... See more keywords
Deoxyarbutin attenuates severe acute pancreatitis via the HtrA2/PGC-1α pathway
Sign Up to like & getrecommendations! Published in 2022 at "Free Radical Research"
DOI: 10.1080/10715762.2022.2163244
Abstract: Abstract Severe acute pancreatitis (SAP) is an inflammatory disorder of the exocrine pancreas associated with high morbidity and mortality. SAP has been proven to trigger mitochondria dysfunction in the pancreas. We found that Deoxyarbutin (dA)… read more here.
Keywords: severe acute; htra2; htra2 pgc; pgc pathway ... See more keywords
Mitochondrial Serine Protease HTRA2 p.G399S in a Female with Di George Syndrome and Parkinson's Disease
Sign Up to like & getrecommendations! Published in 2018 at "Parkinson's Disease"
DOI: 10.1155/2018/5651435
Abstract: Deletion at 22q11.2 responsible for Di George syndrome (DGs) is a risk factor for early-onset Parkinson's disease (EOPD). To date, all patients reported with 22q11.2 deletions and parkinsonian features are negative for a family history… read more here.
Keywords: george syndrome; htra2; parkinson disease;
HtrA2 Independently Predicts Poor Prognosis and Correlates with Immune Cell Infiltration in Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Oncology"
DOI: 10.1155/2023/4067418
Abstract: High-temperature requirement protein A2 (HtrA2), a mitochondrial protein, is related to apoptosis regulation. However, the role of HtrA2 in hepatocellular carcinoma (HCC) remains unclear. In the present study, we explored the prognostic value and expression… read more here.
Keywords: hepatocellular carcinoma; htra2; immune cell; hcc ... See more keywords
DL-3-n-butylphthalide Attenuates Cerebral Ischemia-Reperfusion Injury By Inhibiting Mitochondrial Omi/HtrA2-Mediated Apoptosis.
Sign Up to like & getrecommendations! Published in 2023 at "Current neurovascular research"
DOI: 10.2174/1567202620666230228100653
Abstract: BACKGROUND Ischemic stroke is a major cause of death and disability worldwide and results from inadequate cerebrovascular blood supply; mitochondrial dysfunction plays an essential role in its pathogenesis. DL-3-n-butylphthalide (NBP) is an effective medicine for… read more here.
Keywords: htra2; apoptosis; cerebral ischemia; omi htra2 ... See more keywords
Unraveling the Dichotomy of Enigmatic Serine Protease HtrA2
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.824846
Abstract: Mitochondrial high-temperature requirement protease A2 (HtrA2) is an integral member of the HtrA family of serine proteases that are evolutionarily conserved from prokaryotes to humans. Involvement in manifold intricate cellular networks and diverse pathophysiological functions… read more here.
Keywords: protease htra2; htra2; protease; serine protease ... See more keywords