HtrA3 is a cellular partner of cytoskeleton proteins and TCP1α chaperonin.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of proteomics"
DOI: 10.1016/j.jprot.2018.02.022
Abstract: The human HtrA3 protease is involved in placentation, mitochondrial homeostasis, stimulation of apoptosis and proposed to be a tumor suppressor. Molecular mechanisms of the HtrA3 functions are poorly understood and knowledge concerning its cellular targets… read more here.
Keywords: htra3; cytoskeleton; htra3l; actin tubulin ... See more keywords
A distinct concerted mechanism of structural dynamism defines activity of human serine protease HtrA3
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical Journal"
DOI: 10.1042/bcj20190706
Abstract: Human HtrA3 (high-temperature requirement protease A3) is a trimeric multitasking propapoptotic serine protease associated with critical cellular functions and pathogenicity. Implicated in diseases including cancer and pre-eclampsia, its role as a tumor suppressor and potential… read more here.
Keywords: htra3; distinct concerted; activity; serine protease ... See more keywords