Phenotype onset in Huntington’s disease knock‐in mice is correlated with the incomplete splicing of the mutant huntingtin gene
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24493
Abstract: Huntington’s disease (HD) is a progressive neurodegenerative disorder caused by an expanded CAG repeat within the huntingtin (HTT) gene. The Q140 and HdhQ150 knock‐in HD mouse models were generated such that HdhQ150 mice have an… read more here.
Keywords: knock; htt; splicing mutant; mice ... See more keywords
A Positron Emission Tomography Ligand for Mutant Huntingtin Sheds Light on Disease
Sign Up to like & getrecommendations! Published in 2022 at "Movement Disorders"
DOI: 10.1002/mds.29019
Abstract: Huntington ’ s disease, a rare dominant degenerative disorder, manifests with neuropsychiatric changes and progres-sive cognitive and motor impairments. These diverse clinical manifestations re fl ect neurodegeneration initially in striatal medium spiny neurons and progressing… read more here.
Keywords: positron emission; htt; disease; mutant htt ... See more keywords
Principles and applications of nanomaterial-based hyperthermia in cancer therapy
Sign Up to like & getrecommendations! Published in 2020 at "Archives of Pharmacal Research"
DOI: 10.1007/s12272-020-01206-5
Abstract: Over the past few decades, hyperthermia therapy (HTT) has become one of the most promising strategies to treat cancer. HTT has been applied with nanotechnology to overcome drawbacks such as non-selectivity and invasiveness and to… read more here.
Keywords: nanotechnology; therapy; htt; hyperthermia ... See more keywords
A Comprehensive Haplotype Targeting Strategy for Allele-Specific HTT Suppression in Huntington Disease.
Sign Up to like & getrecommendations! Published in 2019 at "American journal of human genetics"
DOI: 10.1016/j.ajhg.2019.10.011
Abstract: Huntington disease (HD) is a fatal neurodegenerative disorder caused by a gain-of-function mutation in HTT. Suppression of mutant HTT has emerged as a leading therapeutic strategy for HD, with allele-selective approaches targeting HTT SNPs now… read more here.
Keywords: comprehensive haplotype; htt; allele specific; strategy ... See more keywords
Effects of hydrothermal treatment on the pyrolysis behavior of Chinese fan palm.
Sign Up to like & getrecommendations! Published in 2018 at "Bioresource technology"
DOI: 10.1016/j.biortech.2017.09.142
Abstract: The effect of hydrothermal treatment (HTT) on Chinese fan palm pyrolysis was investigated. It indicated that HTT could effectively remove a large portion of alkali/alkaline earth metals and disrupt the chemical structure to a certain… read more here.
Keywords: chinese fan; htt; pyrolysis; hydrothermal treatment ... See more keywords
5-HTT mRNA level as a potential biomarker of treatment response in patients with major depression in a clinical trial.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2018.06.035
Abstract: OBJECTIVES To investigate whether the serotonin transporter (5-HTT or SERT or SLC6A4) mRNA level could be used as a biomarker of treatment response in patients with major depression treated with different antidepressants while controlling related… read more here.
Keywords: mrna level; treatment response; htt; htt mrna ... See more keywords
6-Hexyl-1,2,4,5-tetrazinane-3-thione: Flotation selectivity and mechanism to copper sulfide mineral
Sign Up to like & getrecommendations! Published in 2020 at "Minerals Engineering"
DOI: 10.1016/j.mineng.2020.106345
Abstract: Abstract The floatability of chalcopyrite and pyrite by using 6-hexyl-1,2,4,5-tetrazinane-3-thione (HTT) as a collector was evaluated in the paper. In comparison with the traditional-type collector sodium hexyl xanthate (SHX), HTT exhibited the favorable flotation affinity… read more here.
Keywords: htt; copper; flotation; tetrazinane thione ... See more keywords
Huntingtin-Mediated Multipolar-Bipolar Transition of Newborn Cortical Neurons Is Critical for Their Postnatal Neuronal Morphology
Sign Up to like & getrecommendations! Published in 2017 at "Neuron"
DOI: 10.1016/j.neuron.2016.11.035
Abstract: In the developing cortex, projection neurons undergo multipolar-bipolar transition, radial-directed migration, and maturation. The contribution of these developmental steps to the structure of the adult cortex is not completely understood. Here, we report that huntingtin… read more here.
Keywords: htt; multipolar bipolar; projection neurons; neuronal morphology ... See more keywords
The Polyglutamine Expansion at the N-Terminal of Huntingtin Protein Modulates the Dynamic Configuration and Phosphorylation of the C-Terminal HEAT Domain.
Sign Up to like & getrecommendations! Published in 2020 at "Structure"
DOI: 10.1016/j.str.2020.06.008
Abstract: The polyQ expansion in huntingtin protein (HTT) is the prime cause of Huntington's disease (HD). The recent cryoelectron microscopy (cryo-EM) structure of HTT-HAP40 complex provided the structural information on its HEAT-repeat domains. Here, we present… read more here.
Keywords: htt; expansion; huntingtin protein; terminal ... See more keywords
A New Chemoenzymatic Semisynthetic Approach Provides Insight into the Role of Phosphorylation beyond Exon1 of Huntingtin and Reveals N-Terminal Fragment Length-Dependent Distinct Mechanisms of Aggregation.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c03108
Abstract: Huntington's disease is a neurodegenerative disorder caused by the expansion of a polyglutamine repeat (>36Q) in the N-terminal domain of the huntingtin protein (Htt), which renders the protein or fragments thereof more prone to aggregate… read more here.
Keywords: aggregation; htt; new chemoenzymatic; chemoenzymatic semisynthetic ... See more keywords
A comprehensive in silico analysis of huntingtin and its interactome
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2017.1381646
Abstract: A polyglutamine expansion of the N-terminal region of huntingtin (Htt) causes Huntington’s disease, a severe neurodegenerative disorder. Htt huge multidomain structure, the presence of disordered regions, and the lack of sequence homologs of known structure,… read more here.
Keywords: huntingtin; htt; comprehensive silico; silico analysis ... See more keywords