Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression
Sign Up to like & getrecommendations! Published in 2018 at "Molecular psychiatry"
DOI: 10.1038/mp.2017.44
Abstract: The hypothesis that the S allele of the 5-HTTLPR serotonin transporter promoter region is associated with increased risk of depression, but only in individuals exposed to stressful situations, has generated much interest, research and controversy… read more here.
Keywords: depression; analysis; meta; httlpr genotype ... See more keywords
Structural brain changes with lifetime trauma and re-experiencing symptoms is 5-HTTLPR genotype-dependent
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Psychotraumatology"
DOI: 10.1080/20008198.2020.1733247
Abstract: ABSTRACT Background: Findings on structural brain alterations following trauma are inconsistent due probably to heterogeneity in imaging studies and population, clinical presentations, genetic vulnerability, and selection of controls. This study examines whether trauma and re-experiencing… read more here.
Keywords: experiencing symptoms; lifetime trauma; trauma experiencing; httlpr genotype ... See more keywords