Identifying the hub gene and immune infiltration of osteoarthritis by bioinformatical methods
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Rheumatology"
DOI: 10.1007/s10067-020-05311-0
Abstract: Nowadays, there are more and more people who have been diagnosed osteoarthritis (OA). However, due to the complex changes of OA, the treatment outcome is not very well. In order to improve this situation, I… read more here.
Keywords: hub gene; identifying hub; osteoarthritis; immune infiltration ... See more keywords
LUM is the hub gene of advanced fibrosis in nonalcoholic fatty liver disease patients.
Sign Up to like & getrecommendations! Published in 2020 at "Clinics and research in hepatology and gastroenterology"
DOI: 10.1016/j.clinre.2020.04.006
Abstract: INTRODUCTION Advanced fibrosis in nonalcoholic fatty liver disease (NAFLD) is associated with a poor prognosis. The genetic factors contributing to fibrosis in NAFLD have been described. However, the genetic mechanism and hub genes of advanced… read more here.
Keywords: hub gene; fibrosis nonalcoholic; nonalcoholic fatty; gene ... See more keywords
Interleukin 2 receptor subunit beta as a novel hub gene plays a potential role in the immune microenvironment of abdominal aortic aneurysms.
Sign Up to like & getrecommendations! Published in 2022 at "Gene"
DOI: 10.1016/j.gene.2022.146472
Abstract: BACKGROUND Abdominal aortic aneurysm (AAA) is potentially life threatening and characterized by immune-inflammatory cell infiltration and extracellular matrix degradation. Currently, pharmacotherapy mainly aims to control risk factors without reversion of the dilated aorta. This study… read more here.
Keywords: hub; hub gene; infiltration; gene ... See more keywords
Hub gene identification and prognostic model construction for isocitrate dehydrogenase mutation in glioma
Sign Up to like & getrecommendations! Published in 2020 at "Translational Oncology"
DOI: 10.1016/j.tranon.2020.100979
Abstract: Highlights • We identified ten hub genes which were driving IDH status in GBM and LGG.• We constructed a prognostic model for IDH-mutant patients.• Our findings have important clinical implications for accurate treatment in glioma. read more here.
Keywords: hub gene; glioma; hub; prognostic model ... See more keywords
Identification of key genes involved in type 2 diabetic islet dysfunction: a bioinformatics study
Sign Up to like & getrecommendations! Published in 2019 at "Bioscience Reports"
DOI: 10.1042/bsr20182172
Abstract: Aims: To identify the key differentially expressed genes (DEGs) in islet and investigate their potential pathway in the molecular process of type 2 diabetes. Methods: Gene Expression Omnibus (GEO) datasets (GSE20966, GSE25724, GSE38642) of type… read more here.
Keywords: hub gene; type diabetes; gene; identification key ... See more keywords
Identification of TNFAIP6 as a hub gene associated with the progression of glioblastoma by weighted gene co‐expression network analysis
Sign Up to like & getrecommendations! Published in 2022 at "IET Systems Biology"
DOI: 10.1049/syb2.12046
Abstract: Abstract This study aims to discover the genetic modules that distinguish glioblastoma multiforme (GBM) from low‐grade glioma (LGG) and identify hub genes. A co‐expression network is constructed using the expression profiles of 28 GBM and… read more here.
Keywords: expression; hub gene; analysis; gene expression ... See more keywords
Hub Gene Screening Associated with Early Glaucoma: An Integrated Bioinformatics Analysis
Sign Up to like & getrecommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2022/8030243
Abstract: Background Primary open-angle glaucoma (POAG) is the most common type of glaucoma. The potential influence of some DEGs on the progression of POAG was still incomplete. In this study, we integrated transcriptome data with clinical… read more here.
Keywords: glaucoma; bioinformatics analysis; hub gene; analysis ... See more keywords
The Comprehensive Analysis of Hub Gene ARRB2 in Prostate Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/8518378
Abstract: Methods The differential expressed genes (DEGs) were screened from the gene expression profile GSE30994 related to PRAD and then analyzed by protein-protein interaction (PPI) to screen the hub gene. Subsequently, the relation between hub gene… read more here.
Keywords: hub gene; gene; analysis; prad cell ... See more keywords
IFI44 is an immune evasion biomarker for SARS-CoV-2 and Staphylococcus aureus infection in patients with RA
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1013322
Abstract: Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a global pandemic of severe coronavirus disease 2019 (COVID-19). Staphylococcus aureus is one of the most common pathogenic bacteria in humans, rheumatoid arthritis (RA) is among… read more here.
Keywords: hub genes; infection; hub gene; gene ... See more keywords
Identification of Molecular Signatures and Candidate Drugs in Vascular Dementia by Bioinformatics Analyses
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.751044
Abstract: Vascular dementia (VaD) is considered to be the second most common form of dementia after Alzheimer’s disease, and no specific drugs have been approved for VaD treatment. We aimed to identify shared transcriptomic signatures between… read more here.
Keywords: vascular dementia; interaction; hub gene; gene ... See more keywords
Integrated PPI- and WGCNA-Retrieval of Hub Gene Signatures Shared Between Barrett's Esophagus and Esophageal Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.00881
Abstract: Esophageal adenocarcinoma (EAC) is a deadly cancer with high mortality rate, especially in economically advanced countries, while Barrett's esophagus (BE) is reported to be a precursor that strongly increases the risk of EAC. Due to… read more here.
Keywords: wgcna; hub gene; esophageal adenocarcinoma; gene signatures ... See more keywords