Identification of key modules and hub genes in glioblastoma multiforme based on co‐expression network analysis
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13078
Abstract: Glioblastoma multiforme (GBM) is the most malignant primary tumour in the central nervous system, but the molecular mechanisms underlying its pathogenesis remain unclear. In this study, data set GSE50161 was used to construct a co‐expression… read more here.
Keywords: analysis; hub genes; glioblastoma multiforme; expression ... See more keywords
dentification of intrinsically disordered regions in hub genes of acute myeloid leukemia: a bioinformatics approach.
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2287
Abstract: Acute myeloid leukemia (AML) is the most common acute leukemia in adults. Over the past decades, there has been a great challenge in the treatment of AML. A combination of gene expression profiling with computational… read more here.
Keywords: myeloid leukemia; hub genes; acute myeloid; leukemia ... See more keywords
Identification of gene coexpression modules, hub genes, and pathways related to spinal cord injury using integrated bioinformatics methods
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27908
Abstract: Spinal cord injury (SCI) is characterized by dramatic neurons loss and axonal regeneration suppression. The underlying mechanism associated with SCI‐induced immune suppression is still unclear. Weighted gene coexpression network analysis (WGCNA) is now widely applied… read more here.
Keywords: gene coexpression; hub genes; modules hub; gene ... See more keywords
Identification of key biomarkers in diabetic nephropathy via bioinformatic analysis
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DOI: 10.1002/jcb.28155
Abstract: Diabetic nephropathy (DN) is a major cause of end‐stage renal disease. Although intense efforts have been made to elucidate the pathogenesis, the molecular mechanisms of DN remain to be clarified. To identify the candidate genes… read more here.
Keywords: identification key; analysis; hub genes; biomarkers diabetic ... See more keywords
Identifying novel biomarkers in hepatocellular carcinoma by weighted gene co‐expression network analysis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28420
Abstract: Hepatocellular carcinoma (HCC) is a highly malignant tumor found in the bile duct epithelial cells, and the second most common tumor of the liver. However, the pivotal roles of most molecules of tumorigenesis in HCC… read more here.
Keywords: hcc; analysis; hub genes; gene expression ... See more keywords
Weighted gene coexpression network analysis identifies specific transcriptional modules and hub genes related to intramuscular fat traits in chicken breast muscle
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28636
Abstract: Intramuscular fat (IMF) traits are important factors that influence meat quality. However, the molecular regulatory mechanisms that underlie this trait in chickens are still poorly understood at the gene coexpression level. Here, we performed a… read more here.
Keywords: intramuscular fat; analysis; hub genes; gene coexpression ... See more keywords
Mining TCGA database for screening and identification of hub genes in kidney renal clear cell carcinoma microenvironment
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29511
Abstract: To evaluate the diagnosis and prognosis of the tumor microenvironment (immunization and stromal cells) in kidney renal clear cell carcinoma (KIRC), KIRC cases selected from The Cancer Genome Atlas database were divided into two groups… read more here.
Keywords: microenvironment; renal clear; kidney renal; hub genes ... See more keywords
Integrated bioinformatics analysis of potential biomarkers for pancreatic cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of clinical laboratory analysis"
DOI: 10.1002/jcla.24381
Abstract: BACKGROUND Pancreatic cancer, particularly pancreatic ductal adenocarcinoma (PDA), is an aggressive malignancy associated with a low 5-year survival rate. Poor outcomes associated with PDA are attributable to late detection and inoperability. Most patients with PDA… read more here.
Keywords: expression; progression; hub genes; pda ... See more keywords
Bioinformatic identification of key pathways, hub genes, and microbiota for therapeutic intervention in Helicobacter pylori infection
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29925
Abstract: The pathogenic mechanisms of Helicobacter pylori infection remain to be defined, and potential interventional microbiota are just beginning to be identified. In this study, gene‐set enrichment analysis (GSEA) was used to integrate three H. pylori… read more here.
Keywords: hub genes; infection; pylori infection; helicobacter pylori ... See more keywords
Machine learning to identify immune-related biomarkers of rheumatoid arthritis based on WGCNA network
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Rheumatology"
DOI: 10.1007/s10067-021-05960-9
Abstract: This study was designed to identify the potential diagnostic biomarkers of rheumatoid arthritis (RA) and to explore the potential pathological relevance of immune cell infiltration in this disease. Three previously published datasets containing gene expression… read more here.
Keywords: machine; diagnostic biomarkers; infiltration; hub genes ... See more keywords
Identification of Acute Pancreatitis-Related Genes and Pathways by Integrated Bioinformatics Analysis
Sign Up to like & getrecommendations! Published in 2019 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-019-05928-5
Abstract: Background and Aims The present study aimed to identify the differential expressed genes that are related to acute pancreatitis. Methods Microarray datasets GSE109227 and GSE3644 were downloaded from the public database and analyzed to screen… read more here.
Keywords: acute pancreatitis; analysis; hub genes; egfr cdh1 ... See more keywords