Quantifying cooperative multisite binding in the hub protein LC8 through Bayesian inference
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Computational Biology"
DOI: 10.1101/2022.06.29.498022
Abstract: Multistep protein-protein interactions underlie most biological processes, but their characterization through methods such as isothermal titration calorimetry (ITC) is largely confined to simple models that provide little information on the intermediate, individual steps. In this… read more here.
Keywords: itc; protein lc8; hub protein; protein ... See more keywords
Systematic identification of recognition motifs for the hub protein LC8
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DOI: 10.26508/lsa.201900366
Abstract: LC8 is a eukaryotic hub protein that interacts with multifarious partners; analysis of more than 100 binding/nonbinding sequences led to an algorithm that predicts LC8 partners with 78% accuracy. Hub proteins participate in cellular regulation… read more here.
Keywords: lc8; systematic identification; protein lc8; anchor ... See more keywords
Linker Length Drives Heterogeneity of Multivalent Complexes of Hub Protein LC8 and Transcription Factor ASCIZ
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DOI: 10.3390/biom13030404
Abstract: LC8, a ubiquitous and highly conserved hub protein, binds over 100 proteins involved in numerous cellular functions, including cell death, signaling, tumor suppression, and viral infection. LC8 binds intrinsically disordered proteins (IDPs), and although several… read more here.
Keywords: lc8; hub protein; linker length; heterogeneity multivalent ... See more keywords