Development of a Water-Mediated and Catalyst-Free Green Protocol for Easy Access to a Huge Array of Diverse and Densely Functionalized Pyrido[2,3-d:6,5-d′]dipyrimidines via One-Pot Multicomponent Reaction under Ambient Conditions
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DOI: 10.1021/acssuschemeng.7b02696
Abstract: A water-mediated and catalyst-free simple protocol for easily accessing a huge array of pharmaceutically interesting and diversely functionalized 5-alkyl/aryl/heteroaryl-10-alkyl/aryl-2,8-dioxo/dithioxo-9,10-dihydropyrido[2,3-d:6,5-d′]dipyrimidine-4,6(1H,3H,5H,7H)-dione derivatives 4 (4-1–4-42) and 5,5′-(1,4-phenylene)bis(10-alkyl/aryl-2,8-dioxo/dithioxo-9,10-dihydropyrido[2,3-d:6,5-d′]dipyrimidine-4,6(1H,3H,5H,7H)-dione) 4′ (4′-1–4′-8) has been developed based on a one-pot multicomponent reaction… read more here.
Keywords: water; huge array; water mediated; reaction ... See more keywords