Inhibitors of the protein–protein interaction between phosphorylated p62 and Keap1 attenuate chemoresistance in a human hepatocellular carcinoma cell line
Sign Up to like & getrecommendations! Published in 2020 at "Free Radical Research"
DOI: 10.1080/10715762.2020.1732955
Abstract: Abstract Resistance to anticancer agents has been an obstacle to developing therapeutics and reducing medical costs. Whereas sorafenib is used for the treatment of human hepatocellular carcinoma (HCC), resistance limits its efficacy. p62, a multifunctional… read more here.
Keywords: hepatocellular carcinoma; phosphorylated p62; huh cells; human hepatocellular ... See more keywords
Modulating the Mechanical Resonance of Huh-7 Cells Based on Elasticity of Adhesion Proteins.
Sign Up to like & getrecommendations! Published in 2023 at "IEEE transactions on nanobioscience"
DOI: 10.1109/tnb.2023.3235645
Abstract: The atomic force microscope (AFM) has been used in cell biology for a decade. AFM is a unique tool for investigating the viscoelastic characteristics of live cells in culture and mapping the spatial distribution of… read more here.
Keywords: cell; afm; huh; geometry ... See more keywords
Optimization of Canalicular ABC Transporter Function in HuH-7 Cells by Modification of Culture Conditions
Sign Up to like & getrecommendations! Published in 2019 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.119.087676
Abstract: Human hepatoma cell lines are useful for evaluation of drug-induced hepatotoxicity, hepatic drug disposition, and drug-drug interactions. However, their applicability is compromised by aberrant expression of hepatobiliary transporters. This study was designed to evaluate whether… read more here.
Keywords: canalicular abc; huh; drug; huh cells ... See more keywords
MiR-20a lowers chemosensitivity of liver cancer Huh-7 cells via regulating NF-кB expression.
Sign Up to like & getrecommendations! Published in 2020 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202011_23798
Abstract: OBJECTIVE The aim of this study was to explore the regulatory effect of micro ribonucleic acid (miR)-20a on nuclear factor-κB (NF-кB) in liver cancer Huh-7 cells, and to elucidate its influence on the chemosensitivity of… read more here.
Keywords: mir 20a; expression level; group; expression ... See more keywords
Circular RNA ZNF292 affects proliferation and apoptosis of hepatocellular carcinoma cells by regulating Wnt/β-catenin pathway.
Sign Up to like & getrecommendations! Published in 2020 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202012_24001
Abstract: OBJECTIVE The purpose of this study was to explore the function of circular ribonucleic acid (circRNA) zinc finger protein 292 (ZNF292) in hepatocellular carcinoma (HCC). MATERIALS AND METHODS The expression of circRNA ZNF292 in Huh-7… read more here.
Keywords: apoptosis; proliferation; huh cells; circrna znf292 ... See more keywords
Transcriptome Analysis of Liver Cancer Cell Huh-7 Treated With Metformin
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.822023
Abstract: Metformin is a kind of widely used antidiabetic drug that regulates glucose homeostasis by inhibiting liver glucose production and increasing muscle glucose uptake. Recently, some studies showed that metformin exhibits anticancer properties in a variety… read more here.
Keywords: cell; liver cancer; liver; huh cells ... See more keywords
Cell-cycle and apoptosis related and proteomics-based signaling pathways of human hepatoma Huh-7 cells treated by three currently used multi-RTK inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.944893
Abstract: Sorafenib, lenvatinib and regorafenib, the multi-RTK inhibitors with potent anti-angiogenesis effects, are currently therapeutic drugs generally recommended for the patients with advanced hepatocellular carcinoma (HCC). To date, however, there have been no published studies on… read more here.
Keywords: cell; apoptosis; regorafenib; cell cycle ... See more keywords
Soluble Free, Esterified and Insoluble-Bound Phenolic Antioxidants from Chickpeas Prevent Cytotoxicity in Human Hepatoma HuH-7 Cells Induced by Peroxyl Radicals
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11061139
Abstract: Chickpeas are rich sources of bioactive compounds such as phenolic acids, flavonoids, and isoflavonoids. However, the contribution of insoluble-bound phenolics to their antioxidant properties remains unclear. Four varieties of chickpeas were evaluated for the presence… read more here.
Keywords: free esterified; soluble free; insoluble bound; bound ... See more keywords
Characterization of the RAS/RAF/ERK Signal Cascade as a Novel Regulating Factor in Alpha-Amanitin-Induced Cytotoxicity in Huh-7 Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232012294
Abstract: The well-known hepatotoxicity mechanism resulting from alpha-amanitin (α-AMA) exposure arises from RNA polymerase II (RNAP II) inhibition. RNAP Ⅱ inhibition occurs through the dysregulation of mRNA synthesis. However, the signaling pathways in hepatocytes that arise… read more here.
Keywords: ama exposure; raf erk; alpha amanitin; huh cells ... See more keywords
Antiviral Effects of Clinically-Relevant Interferon-α and Ribavirin Regimens against Dengue Virus in the Hollow Fiber Infection Model (HFIM)
Sign Up to like & getrecommendations! Published in 2018 at "Viruses"
DOI: 10.3390/v10060317
Abstract: Dengue virus (DENV) is the most prevalent mosquito-borne viral illness in humans. Currently, there are no therapeutic agents available to prevent or treat DENV infections. Our objective was to fill this unmet medical need by… read more here.
Keywords: dengue virus; denv; infection; model ... See more keywords
Ebola Virus Isolation Using Huh-7 Cells has Methodological Advantages and Similar Sensitivity to Isolation Using Other Cell Types and Suckling BALB/c Laboratory Mice
Sign Up to like & getrecommendations! Published in 2019 at "Viruses"
DOI: 10.3390/v11020161
Abstract: Following the largest Ebola virus disease outbreak from 2013 to 2016, viral RNA has been detected in survivors from semen and breast milk long after disease recovery. However, as there have been few cases of… read more here.
Keywords: ebola virus; isolation using; laboratory mice; huh cells ... See more keywords