SARS-CoV-2 promote autophagy to suppress type I interferon response
Sign Up to like & getrecommendations! Published in 2021 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-021-00574-8
Abstract: Dear Editor, The outbreak of SARS-CoV-2 leads global epidemic with high morbidity and mortality. However, the pathophysiology of this deadly virus is complex and largely unknown. Autophagy is a highly conserved homeostatic process that allows… read more here.
Keywords: lc3; supplementary fig; sars cov; huh7 cells ... See more keywords
SIRT3 suppression resulting from the enhanced β-catenin signaling drives glycolysis and promotes hypoxia-induced cell growth in hepatocellular carcinoma cells
Sign Up to like & getrecommendations! Published in 2024 at "Cell Cycle"
DOI: 10.1080/15384101.2024.2340864
Abstract: ABSTRACT The precise mechanisms underlying the inhibitory effects of SIRT3, a mitochondrial sirtuin protein, on hepatocellular carcinoma (HCC) development, as well as its impact on mitochondrial respiration, remain poorly understood. We assessed sirtuins 3 (SIRT3)… read more here.
Keywords: huh7 cells; sirt3; hepatocellular carcinoma; cell ... See more keywords
Upregulation of PD-L1 expression promotes epithelial-to-mesenchymal transition in sorafenib-resistant hepatocellular carcinoma cells
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DOI: 10.1093/gastro/goaa049
Abstract: Abstract Background The epithelial-to-mesenchymal transition (EMT) status is associated with programmed death-1 ligand 1 (PD-L1) expression in various cancers. However, the role and molecular mechanism of PD-L1 in the EMT of sorafenib-resistant hepatocellular carcinoma (HCC)… read more here.
Keywords: hcc; sorafenib resistant; hepg2 huh7; huh7 cells ... See more keywords
Cathepsin L and transmembrane serine protease 11E mediate trypsin-independent entry of porcine deltacoronavirus into Huh7 cells
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Virology"
DOI: 10.1128/jvi.01055-25
Abstract: ABSTRACT Porcine deltacoronavirus (PDCoV) is an emerging enteric coronavirus with zoonotic potential. Previous studies showed that PDCoV productive infection is dependent on exogenous trypsin in porcine-derived cells. In this study, we found that trypsin appears… read more here.
Keywords: huh7 cells; trypsin; human derived; derived cells ... See more keywords
Cancer-associated fibroblasts endow stem-like qualities to liver cancer cells by modulating autophagy
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Management and Research"
DOI: 10.2147/cmar.s197634
Abstract: Purpose Both cancer-associated fibroblasts (CAFs) and liver cancer stem cells (LCSCs) play an important part in the tumorigenesis, development and metastasis of hepatocellular carcinoma (HCC). Moreover, the stem-like properties in HCC cells could be promoted… read more here.
Keywords: autophagy; hcc; associated fibroblasts; cancer associated ... See more keywords
A novel strategy of transferring NIS protein to cells using extracellular vesicles leads to increase in iodine uptake and cytotoxicity
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s189738
Abstract: Background This study was designed to explore a novel approach for transferring NIS protein to cells using extracellular vesicle (EV) and enhancing iodine avidity in hepatocellular carcinoma (HCC) cells. Methods We transfected the HCC cells… read more here.
Keywords: nis protein; protein cells; huh7 cells; protein ... See more keywords
Instability of the NS1 Glycoprotein from La Reunion 2018 Dengue 2 Virus (Cosmopolitan-1 Genotype) in Huh7 Cells Is Due to Lysine Residues on Positions 272 and 324
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22041951
Abstract: La Reunion island in the South West Indian Ocean is now endemic for dengue following the introduction of dengue virus serotype 2 (DENV-2) cosmopolitan-I genotype in 2017. DENV-2 infection causes a wide spectrum of clinical… read more here.
Keywords: dengue virus; reunion; huh7 cells; dengue ... See more keywords
Paeonol-mediated apoptosis of hepatocellular carcinoma cells by NF-κB pathway
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DOI: 10.3892/ol.2018.9730
Abstract: The aim of the study was to investigate the effect of paeonol on the apoptosis of hepatocellular carcinoma cells and to explore the possible mechanism of its effect. During the experiment, the human hepatoma (Huh7)… read more here.
Keywords: apoptosis; group group; group; huh7 cells ... See more keywords
Phenethyl isothiocyanate inhibits the carcinogenic properties of hepatocellular carcinoma Huh7.5.1 cells by activating MAPK/PI3K-Akt/p53 signaling pathways
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DOI: 10.7717/peerj.17532
Abstract: Background Hepatocellular carcinoma (HCC) is an aggressive malignancy with limited effective treatment options. Phenethyl isothiocyanate (PEITC) is a bioactive substance present primarily in the cruciferous vegetables. PEITC has exhibited anti-cancer properties in various cancers, including… read more here.
Keywords: huh7; akt p53; huh7 cells; peitc ... See more keywords