Nature of Irreversible Inhibition of Human 20S Proteasome by Salinosporamide A. The Critical Role of Lys–Asp Dyad Revealed from Electrostatic Effects Analysis
Sign Up to like & getrecommendations! Published in 2021 at "ACS Catalysis"
DOI: 10.1021/acscatal.0c05313
Abstract: 20S proteasome is the enzymatic core engine involved in the processes of cellular protein regulation, thus becoming a promising target inter alia in the therapy of many diseases. In this work, the ... read more here.
Keywords: nature irreversible; proteasome salinosporamide; inhibition human; 20s proteasome ... See more keywords
Tetra-anionic porphyrin mimics protein-protein interactions between regulatory particles and the catalytic core, allosterically activating human 20S proteasome
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2025.2482892
Abstract: Abstract Decreased proteasome activity is a hallmark of brain and retinal neurodegenerative diseases (Alzheimer’s, Parkinson’s diseases, glaucoma) boosting the search for molecules acting as proteasome activators. Based on the hypothesis of an electrostatic key code… read more here.
Keywords: tetra anionic; proteasome; human 20s; catalytic core ... See more keywords