Human accelerated genome regions with value in medical genetics and drug discovery.
Sign Up to like & getrecommendations! Published in 2020 at "Drug discovery today"
DOI: 10.1016/j.drudis.2020.03.001
Abstract: Accumulated evolutionary knowledge not only benefits our understanding of the pathogenesis of diseases, but also help in the search for new drug targets. This is further supported by the recent finding that human accelerated regions… read more here.
Keywords: genetics; genetics drug; drug; human accelerated ... See more keywords
Enhancer Function and Evolutionary Roles of Human Accelerated Regions.
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DOI: 10.1146/annurev-genet-071819-103933
Abstract: Human accelerated regions (HARs) are the fastest-evolving sequences in the human genome. When HARs were discovered in 2006, their function was mysterious due to scant annotation of the noncoding genome. Diverse technologies, from transgenic animals… read more here.
Keywords: function evolutionary; enhancer function; human accelerated; accelerated regions ... See more keywords
A Systematic Review of the Human Accelerated Regions in Schizophrenia and Related Disorders: Where the Evolutionary and Neurodevelopmental Hypotheses Converge
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24043597
Abstract: Schizophrenia is a psychiatric disorder that results from genetic and environmental factors interacting and disrupting neurodevelopmental trajectories. Human Accelerated Regions (HARs) are evolutionarily conserved genomic regions that have accumulated human-specific sequence changes. Thus, studies on… read more here.
Keywords: review; related disorders; schizophrenia related; human accelerated ... See more keywords