Molecular basis for drug repurposing to study the interface of the S protein in SARS-CoV-2 and human ACE2 through docking, characterization, and molecular dynamics for natural drug candidates
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-020-04599-8
Abstract: A novel coronavirus (SARS-CoV-2) identified in Wuhan state of China in 2019 is the causative agent of deadly disease COVID-19. It has spread across the globe (more than 210 countries) within a short period. Coronaviruses… read more here.
Keywords: human ace2; drug candidates; protein sars; drug ... See more keywords
Creation of a transgenic mouse model to study the SARS-CoV-2 effect on the pathogenesis of atherosclerosis
Sign Up to like & getrecommendations! Published in 2021 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2021.06.236
Abstract: Background and Aims: The novel coronavirus infection COVID-19 is claiming thousands of lives around the world. The impact of COVID-19 on CVD is actively studied by scientific community. It was found that COVID-19 affects not… read more here.
Keywords: human ace2; pathogenesis; sars cov; gene ... See more keywords
Temperature dependence of the SARS-CoV-2 affinity to human ACE2 determines COVID-19 progression and clinical outcome
Sign Up to like & getrecommendations! Published in 2020 at "Computational and Structural Biotechnology Journal"
DOI: 10.1016/j.csbj.2020.12.005
Abstract: The SARS-CoV-2 virus and its homolog SARS-CoV penetrate human cells by binding of viral spike protein and human angiotensin converting enzyme II (ACE2). SARS-CoV causes high fever in almost all patients, while SARS-CoV-2 does not.… read more here.
Keywords: human ace2; temperature; affinity; temperature dependence ... See more keywords
Structural Modeling of the SARS-CoV-2 Spike/Human ACE2 Complex Interface can Identify High-Affinity Variants Associated with Increased Transmissibility
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Biology"
DOI: 10.1016/j.jmb.2021.167051
Abstract: The COVID-19 pandemic has triggered concerns about the emergence of more infectious and pathogenic viral strains. As a public health measure, efficient screening methods are needed to determine the functional effects of new sequence variants.… read more here.
Keywords: human ace2; high affinity; affinity; structural modeling ... See more keywords
Dynamics of binding ability prediction between spike protein and human ACE2 reveals the adaptive strategy of SARS-CoV-2 in humans
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DOI: 10.1038/s41598-021-82938-2
Abstract: SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is a novel coronavirus causing the COVID-19 pandemic in 2020. High adaptive plasticity on the spike protein of SASR-CoV-2 enables it to transmit across different host species. In… read more here.
Keywords: human ace2; sars cov; spike protein; protein human ... See more keywords
Close relatives of MERS-CoV in bats use ACE2 as their functional receptors
Sign Up to like & getrecommendations! Published in 2022 at "Nature"
DOI: 10.1101/2022.01.24.477490
Abstract: Middle East Respiratory Syndrome coronavirus (MERS-CoV) and several bat coronaviruses employ Dipeptidyl peptidase-4 (DPP4) as their functional receptors1–4. However, the receptor for NeoCoV, the closest MERS-CoV relative yet discovered in bats, remains enigmatic5. In this… read more here.
Keywords: relatives mers; close relatives; mers cov; bats use ... See more keywords
Deciphering the Impact of Mutations on the Binding Efficacy of SARS-CoV-2 Omicron and Delta Variants With Human ACE2 Receptor
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.892093
Abstract: The pandemic of COVID-19, caused by SARS-CoV-2, has globally affected the human health and economy. Since the emergence of the novel coronavirus SARS-CoV-2, the life-threatening virus continues to mutate and evolve. Irrespective of acquired natural… read more here.
Keywords: variants human; ace2 receptor; efficacy; human ace2 ... See more keywords
Human ACE2 Polymorphisms from Different Human Populations Modulate SARS-CoV-2 Infection
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14071451
Abstract: The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in over 6 million deaths worldwide. The high variability in COVID-19 symptoms remains one of the most interesting mysteries of the… read more here.
Keywords: symptomatology; infection; covid; human ace2 ... See more keywords
Generation and Characterization of a SARS-CoV-2-Susceptible Mouse Model Using Adeno-Associated Virus (AAV6.2FF)-Mediated Respiratory Delivery of the Human ACE2 Gene
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v15010085
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of coronavirus disease 2019 (COVID-19) that has caused a pandemic with millions of human infections. There continues to be a pressing need to develop… read more here.
Keywords: respiratory; model; ace2; human ace2 ... See more keywords