Interaction of Aripiprazole with Human α1-Acid Glycoprotein.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2019.09.003
Abstract: We recently reported that aripiprazole binds strongly to human albumin. In continuing our investigations, we investigated the mechanism responsible for the binding and the related interactions of aripiprazole with α1-acid glycoprotein (AGP). The extrinsic Cotton… read more here.
Keywords: acid glycoprotein; interaction aripiprazole; human acid; albumin ... See more keywords
Feasibility Study for Bedside Production of Recombinant Human Acid α-Glucosidase: Technical and Financial Considerations.
Sign Up to like & getrecommendations! Published in 2020 at "Current pharmaceutical biotechnology"
DOI: 10.2174/1389201021666200217113049
Abstract: The high cost of orphan drugs limits their access by many patients, especially in low- and middle-income countries. Many orphan drugs are off-patent without alternative generic or biosimilar versions available. Production of these drugs at… read more here.
Keywords: recombinant human; production; bedside production; human acid ... See more keywords
Immune transgene-dependent myocarditis in macaques after systemic administration of adeno-associated virus expressing human acid alpha-glucosidase
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1094279
Abstract: Immune responses to human non-self transgenes can present challenges in preclinical studies of adeno-associated virus (AAV) gene therapy candidates in nonhuman primates. Although anti-transgene immune responses are usually mild and non-adverse, they can confound pharmacological… read more here.
Keywords: human acid; acid alpha; alpha glucosidase; associated virus ... See more keywords