Rapid neuroinflammatory changes in human acute intracerebral hemorrhage
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.50842
Abstract: Spontaneous intracerebral hemorrhage (ICH) is the commonest form of hemorrhagic stroke and is associated with a poor prognosis. Neurosurgical removal of intracerebral hematoma has limited benefit and no pharmacotherapies are available. In acute ICH, primary… read more here.
Keywords: rapid neuroinflammatory; changes human; intracerebral hemorrhage; neuroinflammatory changes ... See more keywords
Prolonged life of human acute hippocampal slices from temporal lobe epilepsy surgery
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-22554-9
Abstract: Resected hippocampal tissue from patients with drug-resistant epilepsy presents a unique possibility to test novel treatment strategies directly in target tissue. The post-resection time for testing and analysis however is normally limited. Acute tissue slices… read more here.
Keywords: epilepsy; life human; prolonged life; treatment strategies ... See more keywords
Discovery of a novel water-soluble, rapid-release triptolide prodrug with improved drug-like properties and high efficacy in human acute myeloid leukemia.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.2139/ssrn.4137497
Abstract: In this work, a series of water-soluble triptolide prodrugs were synthesized, and their triptolide release rate, pharmacokinetic characteristics and anti-tumor effect were measured. We found that inserting glycolic acid as a linker between triptolide and… read more here.
Keywords: water; release triptolide; human acute; triptolide prodrug ... See more keywords