Canonical Wnt inhibitors ameliorate cystogenesis in a mouse ortholog of human ADPKD.
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DOI: 10.1172/jci.insight.95874
Abstract: Autosomal dominant polycystic kidney disease (ADPKD) can be caused by mutations in the PKD1 or PKD2 genes. The PKD1 gene product is a Wnt cell-surface receptor. We previously showed that a lack of the PKD2… read more here.
Keywords: wnt; catenin signaling; mouse ortholog; catenin ... See more keywords