Studying Werner syndrome to elucidate mechanisms and therapeutics of human aging and age-related diseases
Sign Up to like & getrecommendations! Published in 2019 at "Biogerontology"
DOI: 10.1007/s10522-019-09798-2
Abstract: Aging is a natural and unavoidable part of life. However, aging is also the primary driver of the dominant human diseases, such as cardiovascular disease, cancer, and neurodegenerative diseases, including Alzheimer’s disease. Unraveling the sophisticated… read more here.
Keywords: age related; related diseases; werner syndrome; human aging ... See more keywords
The aging proteostasis decline: From nematode to human
Sign Up to like & getrecommendations! Published in 2021 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2021.112474
Abstract: The aging proteostasis decline manifests in a failure of aging cells and organisms to properly respond to proteotoxic challenges. This proteostasis collapse has long been considered a hallmark of aging in nematodes, and has recently… read more here.
Keywords: proteostasis decline; aging proteostasis; proteostasis; senescence ... See more keywords
Interactomics: Dozens of Viruses, Co-evolving With Humans, Including the Influenza A Virus, may Actively Distort Human Aging
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msad012
Abstract: Abstract Some viruses (e.g., human immunodeficiency virus 1 and severe acute respiratory syndrome coronavirus 2) have been experimentally proposed to accelerate features of human aging and of cellular senescence. These observations, along with evolutionary considerations… read more here.
Keywords: human aging; biology; dozens viruses; cellular senescence ... See more keywords
Mendelian randomization analyses implicate biogenesis of translation machinery in human aging
Sign Up to like & getrecommendations! Published in 2022 at "Genome Research"
DOI: 10.1101/gr.275636.121
Abstract: Reduced provision of protein translation machinery promotes healthy aging in a number of animal models. In humans, however, inborn impairments in translation machinery are a known cause of several developmental disorders, collectively termed ribosomopathies. Here,… read more here.
Keywords: translation machinery; mendelian randomization; human aging; biogenesis translation ... See more keywords
The metabolomics of human aging: Advances, challenges, and opportunities
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.add6155
Abstract: As the global population becomes older, understanding the impact of aging on health and disease becomes paramount. Recent advancements in multiomic technology have allowed for the high-throughput molecular characterization of aging at the population level.… read more here.
Keywords: human aging; metabolomics human; advances challenges; challenges opportunities ... See more keywords
Kynurenine Pathway Metabolites in the Blood and Cerebrospinal Fluid Are Associated with Human Aging
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/5019752
Abstract: The kynurenine pathway is implicated in aging, longevity, and immune regulation, but longitudinal studies and assessment of the cerebrospinal fluid (CSF) are lacking. We investigated tryptophan (Trp) and downstream kynurenine metabolites and their associations with… read more here.
Keywords: kynurenine pathway; cerebrospinal fluid; human aging; age ... See more keywords
Mouse Models to Disentangle the Hallmarks of Human Aging
Sign Up to like & getrecommendations! Published in 2018 at "Circulation Research"
DOI: 10.1161/circresaha.118.312204
Abstract: Model organisms have provided fundamental evidence that aging can be delayed and longevity extended. These findings gave rise to a new era in aging research aimed at elucidating the pathways and networks controlling this complex… read more here.
Keywords: mouse models; disentangle hallmarks; hallmarks human; models disentangle ... See more keywords
Genome-wide prediction and prioritization of human aging genes by data fusion: a machine learning approach
Sign Up to like & getrecommendations! Published in 2019 at "BMC Genomics"
DOI: 10.1186/s12864-019-6140-0
Abstract: BackgroundMachine learning can effectively nominate novel genes for various research purposes in the laboratory. On a genome-wide scale, we implemented multiple databases and algorithms to predict and prioritize the human aging genes (PPHAGE).ResultsWe fused data… read more here.
Keywords: genome wide; human aging; aging genes; prioritization ... See more keywords
Metabolomics to Study Human Aging: A Review.
Sign Up to like & getrecommendations! Published in 2023 at "Current molecular medicine"
DOI: 10.2174/1566524023666230407123727
Abstract: In the last years, with the increase in the average life expectancy, the world's population is progressively aging, which entails social, health and economic problems. In this sense, the need to better understand the physiology… read more here.
Keywords: study human; human aging; physiology; aging review ... See more keywords
Microbiome and Human Aging: Probiotic and Prebiotic Potentials in Longevity, Skin Health and Cellular Senescence
Sign Up to like & getrecommendations! Published in 2021 at "Nutrients"
DOI: 10.3390/nu13124550
Abstract: The role of the microbiome in human aging is important: the microbiome directly impacts aging through the gastrointestinal system. However, the microbial impact on skin has yet to be fully understood. For example, cellular senescence… read more here.
Keywords: cellular senescence; human aging; skin; microbiome human ... See more keywords