From the Cover: Development and Application of a Dual Rat and Human AHR Activation Assay
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DOI: 10.1093/toxsci/kfx188
Abstract: Significant prolonged aryl hydrocarbon receptor (AHR) activation, classically exhibited following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin, can cause a variety of undesirable toxicological effects. Novel pharmaceutical chemistries also have the potential to cause activation of AHR and consequent… read more here.
Keywords: ahr activation; human ahr; activation; cover development ... See more keywords
Constitutive Activation of the Human Aryl Hydrocarbon Receptor in Mice Promotes Hepatocarcinogenesis Independent of Its Coactivator Gadd45b
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DOI: 10.1093/toxsci/kfy263
Abstract: 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), or dioxin, is a potent liver cancer promoter through its sustained activation of the aryl hydrocarbon receptor (Ahr) in rodents. However, the carcinogenic effect of TCDD and AHR in humans has been controversial.… read more here.
Keywords: ahr; activation human; human ahr; constitutive activation ... See more keywords
NAP Family CG5017 Chaperone Pleiotropically Regulates Human AHR Target Genes Expression in Drosophila Testis
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DOI: 10.3390/ijms20010118
Abstract: To study the regulatory mechanism of the Aryl hydrocarbon receptor (AHR), target genes of transcription are necessary for understanding the normal developmental and pathological processes. Here, we examined the effects of human AHR ligands on… read more here.
Keywords: ahr target; human ahr; expression; target genes ... See more keywords