Mechanistic insights into the ROS-mediated inactivation of human aldehyde oxidase.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS letters"
DOI: 10.1002/1873-3468.14669
Abstract: Human aldehyde oxidase (hAOX1) is a molybdoenzyme that oxidizes aldehydes and N-heterocyclic compounds, thereby generating hydrogen peroxide (H2 O2 ) and superoxide during turnover. hAOX1 has been shown previously to be inactivated under turnover conditions… read more here.
Keywords: aldehyde oxidase; insights ros; ros mediated; human aldehyde ... See more keywords
Interrogating the Inhibition Mechanisms of Human Aldehyde Oxidase by X-ray Crystallography and NMR Spectroscopy: The Raloxifene Case.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01125
Abstract: Human aldehyde oxidase (hAOX1) is mainly present in the liver and has an emerging role in drug metabolism, since it accepts a wide range of molecules as substrates and inhibitors. Herein, we employed an integrative… read more here.
Keywords: inhibition; aldehyde oxidase; ray crystallography; spectroscopy ... See more keywords
Inactivation of Human Aldehyde Oxidase by Small Sulfhydryl-Containing Reducing Agents
Sign Up to like & getrecommendations! Published in 2023 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.122.001244
Abstract: Human aldehyde oxidase (hAOX1) is a molybdoflavoenzyme that belongs to the xanthine oxidase (XO) family. hAOX1 is involved in phase I drug metabolism, but its physiologic role is not fully understood to date, and preclinical… read more here.
Keywords: aldehyde oxidase; sulfhydryl; sulfhydryl containing; human aldehyde ... See more keywords