Computational modeling of amylin-induced calcium dysregulation in rat ventricular cardiomyocytes.
Sign Up to like & getrecommendations! Published in 2018 at "Cell calcium"
DOI: 10.1016/j.ceca.2017.11.006
Abstract: Hyperamylinemia is a condition that accompanies obesity and precedes type II diabetes, and it is characterized by above-normal blood levels of amylin, the pancreas-derived peptide. Human amylin oligomerizes easily and can deposit in the pancreas… read more here.
Keywords: calcium dysregulation; amylin induced; human amylin; ca2 ... See more keywords
Physico-chemical stability of co-formulation of PEGylated human amylin with insulin
Sign Up to like & getrecommendations! Published in 2019 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2019.1621896
Abstract: Abstract Since the discovery of amylin no combined formulation with insulin has been made available. Amylin or its triple proline analog pramlintide are not compatible in solution with insulin. The drug candidate hAmy-PEG5k is a… read more here.
Keywords: insulin; hamy peg5k; glargine detemir; human amylin ... See more keywords