Molecular dynamics analysis of phytochemicals from Ageratina adenophora against COVID-19 main protease (Mpro) and human angiotensin-converting enzyme 2 (ACE2)
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DOI: 10.1016/j.bcab.2021.101924
Abstract: The outbreak of COVID-19 created unprecedented strain in the healthcare system. Various research revealed that COVID-19 main protease (Mpro) and human angiotensin-converting enzyme 2 (ACE2) are responsible for viral replication and entry into the human… read more here.
Keywords: covid main; mpro human; molecular dynamics; main protease ... See more keywords
Hamsters Expressing Human Angiotensin-Converting Enzyme 2 Develop Severe Disease following Exposure to SARS-CoV-2
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DOI: 10.1128/mbio.02906-21
Abstract: The rapid emergence of SARS-CoV-2 has created a global health emergency. While most human SARS-CoV-2 disease is mild, some people develop severe, life-threatening disease. ABSTRACT The rapid emergence of severe acute respiratory syndrome coronavirus 2… read more here.
Keywords: severe disease; sars cov; develop severe; human angiotensin ... See more keywords
Rapid Assessment of Binding Affinity of SARS-COV-2 Spike Protein to the Human Angiotensin-Converting Enzyme 2 Receptor and to Neutralizing Biomolecules Based on Computer Simulations
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DOI: 10.3389/fimmu.2021.730099
Abstract: SARS-CoV-2 infects humans and causes Coronavirus disease 2019 (COVID-19). The S1 domain of the spike glycoprotein of SARS-CoV-2 binds to human angiotensin-converting enzyme 2 (hACE2) via its receptor-binding domain, while the S2 domain facilitates fusion… read more here.
Keywords: sars cov; human angiotensin; binding affinity; angiotensin converting ... See more keywords
An Insight Based on Computational Analysis of the Interaction between the Receptor-Binding Domain of the Omicron Variants and Human Angiotensin-Converting Enzyme 2
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DOI: 10.3390/biology11050797
Abstract: Simple Summary The Omicron variant has recently been divided into BA.1, BA.2, and BA.3 subvariants. In the present study, we focused on comparing the interaction between the receptor-binding domain (RBD) of BA.1 and BA.2 spike… read more here.
Keywords: interaction; interaction receptor; receptor binding; omicron ... See more keywords
Mutations of Omicron Variant at the Interface of the Receptor Domain Motif and Human Angiotensin-Converting Enzyme-2
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DOI: 10.3390/ijms23052870
Abstract: The most recent Omicron variant of SARS-CoV-2 has caused global concern and anxiety. The only thing certain about this strain, with large number of mutations in the spike protein, is that it spreads quickly, seems… read more here.
Keywords: converting enzyme; omicron variant; human angiotensin; mutations omicron ... See more keywords