Pathogenicity of human antibodies against myelin oligodendrocyte glycoprotein
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Neurology"
DOI: 10.1002/ana.25291
Abstract: Autoantibodies against myelin oligodendrocyte glycoprotein (MOG) occur in a proportion of patients with inflammatory demyelinating diseases of the central nervous system (CNS). We analyzed their pathogenic activity by affinity‐purifying these antibodies (Abs) from patients and… read more here.
Keywords: myelin oligodendrocyte; antibodies myelin; pathogenicity human; human antibodies ... See more keywords
Pan-protective anti-alphavirus human antibodies target a conserved E1 protein epitope
Sign Up to like & getrecommendations! Published in 2021 at "Cell"
DOI: 10.1016/j.cell.2021.07.006
Abstract: Alphaviruses are emerging, mosquito-transmitted pathogens that cause musculoskeletal and neurological disease in humans. Although neutralizing antibodies that inhibit individual alphaviruses have been described, broadly reactive antibodies that protect against both arthritogenic and encephalitic alphaviruses have… read more here.
Keywords: pan protective; anti alphavirus; alphavirus human; protective anti ... See more keywords
Pan-ebolavirus protective therapy by two multifunctional human antibodies
Sign Up to like & getrecommendations! Published in 2021 at "Cell"
DOI: 10.1016/j.cell.2021.09.035
Abstract: Ebolaviruses cause a severe and often fatal illness with the potential for global spread. Monoclonal antibody-based treatments that have become available recently have a narrow therapeutic spectrum and are ineffective against ebolaviruses other than Ebola… read more here.
Keywords: ebolavirus protective; pan ebolavirus; therapy two; human antibodies ... See more keywords
Human antibodies eluted from ligand-free Sepharose capable of binding bacterial polysaccharides and sulfated glycans.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular immunology"
DOI: 10.1016/j.molimm.2018.12.011
Abstract: Sepharose matrix without immobilized ligands binds antibodies from human blood serum or immunoglobulin preparations. The eluted antibodies bind bacterial polysaccharides having no structural similarity to agarose (Sepharose is a cross-linked polysaccharide agarose) with a high… read more here.
Keywords: sepharose; ligand free; antibodies eluted; human antibodies ... See more keywords
Human antibodies targeting Zika virus NS1 provide protection against disease in a mouse model
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-07008-0
Abstract: Zika virus is a mosquito-borne flavivirus closely related to dengue virus that can cause severe disease in humans, including microcephaly in newborns and Guillain-Barré syndrome in adults. Specific treatments and vaccines for Zika virus are… read more here.
Keywords: protection; disease; human antibodies; antibodies targeting ... See more keywords
Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis
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DOI: 10.1038/s41467-021-20930-0
Abstract: Mycobacterium tuberculosis (Mtb) exposure drives antibody responses, but whether patients with active tuberculosis elicit protective antibodies, and against which antigens, is still unclear. Here we generate monoclonal antibodies from memory B cells of one patient… read more here.
Keywords: mycobacterium; mtb; human antibodies; psts1 ... See more keywords
Human antibodies against DBP
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DOI: 10.1038/s41564-019-0549-8
Abstract: Duffy-binding protein (DBP) is the leading vaccine candidate for Plasmodium vivax malaria. Two studies express and characterise the first human monoclonal antibodies against DBP, induced by natural infection and vaccination, showing they have in vitro… read more here.
Keywords: human antibodies; antibodies dbp; microbiology;
Human antibodies against non-circumsporozoite proteins block Plasmodium falciparum parasite development in hepatocytes.
Sign Up to like & getrecommendations! Published in 2022 at "JCI insight"
DOI: 10.1172/jci.insight.153524
Abstract: Sporozoite-based approaches currently represent the most effective vaccine strategies for induction of sterile protection against Plasmodium falciparum (Pf) malaria. Clinical development of sub-unit vaccines is almost exclusively centered around the Circum-sporozoite Protein (CSP) an abundantly… read more here.
Keywords: development; plasmodium falciparum; human antibodies; csp ... See more keywords
Human antibodies targeting ENPP1 as candidate therapeutics for cancers
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1070492
Abstract: Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is a type II transmembrane glycoprotein expressed in many tissues. High expression levels of ENPP1 have been observed in many cancer types such as lung cancer, ovarian cancer, and breast cancer.… read more here.
Keywords: targeting enpp1; enpp1 candidate; candidate therapeutics; human antibodies ... See more keywords
Monoclonal Human Antibodies That Recognise the Exposed N and C Terminal Regions of the Often-Overlooked SARS-CoV-2 ORF3a Transmembrane Protein
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DOI: 10.3390/v13112201
Abstract: ORF3a has been identified as a viroporin of SARS-CoV-2 and is known to be involved in various pathophysiological activities including disturbance of cellular calcium homeostasis, inflammasome activation, apoptosis induction and disruption of autophagy. ORF3a-targeting antibodies… read more here.
Keywords: monoclonal human; sars cov; human antibodies; transmembrane protein ... See more keywords