Development and characterization of a fully human antibody targeting SCF/c-kit signaling.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.05.045
Abstract: CD117/c-kit, a tyrosine kinase receptor, plays a critical role in hematopoiesis, pigmentation, and fertility. The overexpression and activation of c-kit are thought to promote tumor growth and have been reported in various cancers, including leukemia,… read more here.
Keywords: human antibody; development characterization; antibody; kit signaling ... See more keywords
A synthetic human antibody antagonizes IL-18Rβ signaling through an allosteric mechanism.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2020.01.012
Abstract: The interleukin-18 subfamily belongs to the interleukin-1 family and plays important roles in modulating innate and adaptive immune responses. Dysregulation of IL-18 has been implicated in or correlated with numerous diseases including inflammatory diseases, autoimmune… read more here.
Keywords: antibody antagonizes; allosteric mechanism; synthetic human; human antibody ... See more keywords
Combination of phage and Gram-positive bacterial display of human antibody repertoires enables isolation of functional high affinity binders.
Sign Up to like & getrecommendations! Published in 2018 at "New biotechnology"
DOI: 10.1016/j.nbt.2017.07.011
Abstract: Surface display couples genotype with a surface exposed phenotype and thereby allows screening of gene-encoded protein libraries for desired characteristics. Of the various display systems available, phage display is by far the most popular, mainly… read more here.
Keywords: gram positive; positive bacterial; human antibody; affinity ... See more keywords
Different classes of genomic inserts contribute to human antibody diversity
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2205470119
Abstract: Significance The enormous diversity of antibodies is a key element to combat infections. Antibodies containing pathogen receptors were a surprising discovery that contrasted antibody diversification through classic recombination events. However, such insert-containing antibodies were thus… read more here.
Keywords: human antibody; diversity; different classes; classes genomic ... See more keywords
Inhibition of HER3 activation and tumor growth with a human antibody binding to a conserved epitope formed by domain III and IV
Sign Up to like & getrecommendations! Published in 2017 at "mAbs"
DOI: 10.1080/19420862.2017.1319023
Abstract: ABSTRACT Human epidermal growth factor receptor 3 (HER3, also known as ErbB3) has emerged as relevant target for antibody-mediated tumor therapy. Here, we describe a novel human antibody, IgG 3–43, recognizing a unique epitope formed… read more here.
Keywords: epitope formed; human antibody; her3; growth ... See more keywords
The human antibody sequence space and structural design of the V, J regions, and CDRH3 with Rosetta
Sign Up to like & getrecommendations! Published in 2022 at "mAbs"
DOI: 10.1080/19420862.2022.2068212
Abstract: ABSTRACT The human adaptive immune response enables the targeting of epitopes on pathogens with high specificity. Infection with a pathogen induces somatic hyper-mutation and B-cell selection processes that govern the shape and diversity of the… read more here.
Keywords: antibody sequence; sequence space; human antibody; sequence ... See more keywords
Abstract LB-002: A fully human antibody binds Tn and sTn carbohydrate antigens specifically on serine residues, without need for polypeptide interaction
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-lb-002
Abstract: Background: Thompsen-nouvelle (Tn) antigen is an O-linked glycan that is associated with a broad array of tumors. Tn is a single alpha-linked GalNAc added to Ser or Thr as the first step of a major… read more here.
Keywords: human antibody; thr; antibody; fully human ... See more keywords
Enhancement of therapeutic potential of a naturally occurring human antibody targeting a phosphorylated Ser422 containing epitope on pathological tau
Sign Up to like & getrecommendations! Published in 2018 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-018-0562-9
Abstract: Aggregation of tau protein and spreading of tau aggregates are pivotal pathological processes in a range of neurological disorders. Accumulating evidence suggests that immunotherapy targeting tau may be a viable therapeutic strategy. We have previously… read more here.
Keywords: tau; human antibody; antibody; pathological tau ... See more keywords
Generation of a Nebulizable CDR-Modified MERS-CoV Neutralizing Human Antibody
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20205073
Abstract: Middle East respiratory syndrome coronavirus (MERS-CoV) induces severe aggravating respiratory failure in infected patients, frequently resulting in mechanical ventilation. As limited therapeutic antibody is accumulated in lung tissue following systemic administration, inhalation is newly recognized… read more here.
Keywords: human antibody; residues replaced; neutralizing human; antibody ... See more keywords