Thrombospondins in human aortic aneurysms
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DOI: 10.1002/iub.2610
Abstract: Thrombospondins are a family of matricellular proteins with a multimeric structure that is known to be involved in several biological and pathological processes. Their relationship with vascular disorders has raised special interest recently. Aortic aneurysms… read more here.
Keywords: aortic aneurysms; human samples; role; thrombospondins human ... See more keywords
The metabolic analysis in human aortic tissues of aortic dissection
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DOI: 10.1002/jcla.24623
Abstract: The metabolic profile of human aortic tissues is of great importance. Among the analytical platforms utilized in metabolomics, LC‐MS provides broad metabolome coverage. The non‐targeted metabolomics can comprehensively detect the entire metabolome of an organism… read more here.
Keywords: aortic tissues; human aortic; aortic dissection; metabolic analysis ... See more keywords
Suppression of Lysophosphatidylcholine-Induced Human Aortic Smooth Muscle Cell Calcification by Protein Kinase A Inhibition.
Sign Up to like & getrecommendations! Published in 2019 at "Lipids"
DOI: 10.1002/lipd.12178
Abstract: Lysophosphatidylcholine (lysoPtdCho) is produced mainly by the phospholipase A2-dependent hydrolysis of phosphatidylcholine (PtdCho) and can induce inflammatory activation and osteogenic gene expression in vascular smooth muscle cells. However, the mechanisms mediating these processes have not… read more here.
Keywords: calcification; aortic smooth; smooth muscle; protein kinase ... See more keywords
In vitro biomechanical and hydrodynamic characterisation of decellularised human pulmonary and aortic roots.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the mechanical behavior of biomedical materials"
DOI: 10.1016/j.jmbbm.2017.09.019
Abstract: BACKGROUND AND PURPOSE OF THE STUDY The use of decellularised biological heart valves in the replacement of damaged heart valves offers a promising solution to reduce the degradation issues associated with existing cryopreserved allografts. The… read more here.
Keywords: biomechanical hydrodynamic; aortic pulmonary; pulmonary roots; vitro biomechanical ... See more keywords
Mechanical and structural properties of different types of human aortic atherosclerotic plaques.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the mechanical behavior of biomedical materials"
DOI: 10.1016/j.jmbbm.2020.103837
Abstract: Atherosclerotic plaques are characterized by structural heterogeneity affecting aortic behaviour under mechanical loading. There is evidence of direct connections between the structural plaque arrangement and the risk of plaque rupture. As a consequence of aortic… read more here.
Keywords: atherosclerotic plaques; different types; types human; plaque ... See more keywords
Asiatic acid stabilizes cytoskeletal proteins and prevents TNF-α-induced disorganization of cell-cell junctions in human aortic endothelial cells.
Sign Up to like & getrecommendations! Published in 2019 at "Vascular pharmacology"
DOI: 10.1016/j.vph.2018.08.005
Abstract: Endothelial hyperpermeability represents an initiating step in early atherosclerosis and it often occurs as a result of endothelial barrier dysfunction. Asiatic acid, a major triterpene isolated from Centella asiatica (L.) Urban, has previously been demonstrated… read more here.
Keywords: tnf induced; aortic endothelial; asiatic acid; acid ... See more keywords
miR-185/P2Y6 Axis Inhibits Angiotensin II-Induced Human Aortic Vascular Smooth Muscle Cell Proliferation.
Sign Up to like & getrecommendations! Published in 2017 at "DNA and Cell Biology"
DOI: 10.1089/dna.2016.3605
Abstract: The abnormal proliferation and apoptosis of human aortic vascular smooth muscle cells (HAVSMCs) play an important role in the pathogenesis of hypertension. Recent study revealed that angiotensin II (Ang II) could elicit HAVSMC dysfunction, to… read more here.
Keywords: mir 185; aortic vascular; vascular smooth; proliferation ... See more keywords
Nicotinamide Mononucleotide Alleviates Angiotensin II-Induced Human Aortic Smooth Muscle Cell Senescence in a Microphysiological Model
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000001400
Abstract: Supplemental Digital Content is Available in the Text. Abstract: The occurrence and development of aortic aneurysms are accompanied by senescence of human aortic smooth muscle cells (HASMCs). Because the mechanism of HASMC senescence has not… read more here.
Keywords: cell; nicotinamide mononucleotide; aortic aneurysms; senescence ... See more keywords
Cell-Type Transcriptome Atlas of Human Aortic Valves Reveal Cell Heterogeneity and Endothelial to Mesenchymal Transition Involved in Calcific Aortic Valve Disease
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DOI: 10.1161/atvbaha.120.314789
Abstract: Supplemental Digital Content is available in the text. Objective: Leaflet thickening, fibrosis, and hardening are early pathological features of calcific aortic valve disease (CAVD). An inadequate understanding of the resident aortic valve cells involved in… read more here.
Keywords: valve disease; calcific aortic; human aortic; cell ... See more keywords
Differences in Vasa Vasorum Distribution in Human Aortic Aneurysms and Atheromas
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DOI: 10.1177/00033197211063655
Abstract: The pathophysiological difference between aortic atheromas and aneurysms is unknown. We focused on the vasa vasorum (VV), which play a critical role in maintaining aortic homeostasis and are also involved in vascular diseases. We investigated… read more here.
Keywords: vasa vasorum; aneurysm; differences vasa; human aortic ... See more keywords
T-614 inhibits human aortic adventitial fibroblast proliferation and promotes interleukin-8 production in vitro
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DOI: 10.1177/1708538119880088
Abstract: Objectives The effect and underlying mechanism of T-614 (iguratimod) on Takayasu’s arteritis (TA) are unknown. Here, we report the effects of T-614 on cell proliferation and interleukin-8 (IL-8) production in human aortic adventitial fibroblasts (HAAFs)… read more here.
Keywords: production; presence; proliferation; aortic adventitial ... See more keywords