Identification of small molecule compounds targeting the interaction of HIV-1 Vif and human APOBEC3G by virtual screening and biological evaluation
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DOI: 10.1038/s41598-018-26318-3
Abstract: Human APOBEC3G (hA3G) is a restriction factor that inhibits human immunodeficiency 1 virus (HIV-1) replication. The virally encoded protein Vif binds to hA3G and induces its degradation, thereby counteracting the antiviral activity of hA3G. Vif-mediated… read more here.
Keywords: human apobec3g; small molecule; interaction; vif ... See more keywords
Human APOBEC3G Prevents Emergence of Infectious Endogenous Retrovirus in Mice
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DOI: 10.1128/jvi.00728-19
Abstract: Although APOBEC3 proteins are known to be important antiviral restriction factors in both mice and humans, their roles in the restriction of endogenous retroviruses (ERV) have been limited to in vitro studies. Here, we report… read more here.
Keywords: mice; prevents emergence; human apobec3g; infectious erv ... See more keywords