Mechanism of stimulation of DNA binding of the transcription factors by human apurinic/apyrimidinic endonuclease 1, APE1.
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DOI: 10.1016/j.dnarep.2019.102698
Abstract: Aerobic respiration generates reactive oxygen species (ROS), which can damage nucleic acids, proteins and lipids. A number of transcription factors (TFs) contain redox-sensitive cysteine residues at their DNA-binding sites, hence ROS-induced thiol oxidation strongly inhibits… read more here.
Keywords: human apurinic; dna; ape1; apurinic apyrimidinic ... See more keywords