Human beta-defensins 2 and 4 are dysregulated in patients with coronavirus disease 19
Sign Up to like & getrecommendations! Published in 2021 at "Microbial Pathogenesis"
DOI: 10.1016/j.micpath.2021.105205
Abstract: Antimicrobial peptides (AMPs) have recently been proposed as significant immunological factors involved in pathogenesis of coronavirus disease 19 (COVID-19). Human β-defensins (hBDs) are among these AMPs, but the evidence is not well detailed. Therefore, this… read more here.
Keywords: hbd2; hbd4; covid; beta defensins ... See more keywords
The truncated human beta-defensin 118 can modulate lipopolysaccharide mediated inflammatory response in RAW264.7 macrophages
Sign Up to like & getrecommendations! Published in 2021 at "Peptides"
DOI: 10.1016/j.peptides.2020.170438
Abstract: The family of human β-defensins consists of small cysteine-rich peptides, which are receiving significant attention due to their antimicrobial activity. The N-terminal cysteine motif of β-defensin is considered to contribute to its biological activity. Human… read more here.
Keywords: defensin; raw264; truncated human; defb118 peptide ... See more keywords
Association of human beta‐defensin 1 gene polymorphisms with nonsegmental vitiligo
Sign Up to like & getrecommendations! Published in 2019 at "Clinical and Experimental Dermatology"
DOI: 10.1111/ced.13697
Abstract: Vitiligo is a pigmentation disorder of autoimmune aetiology. Polymorphisms in beta‐defensin genes have been linked to a predisposition to some autoimmune disorders. read more here.
Keywords: defensin; beta defensin; gene polymorphisms; defensin gene ... See more keywords
Preclinical evaluation of tyrosine kinase 2 inhibitors for human beta‐cell protection in type 1 diabetes
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes"
DOI: 10.1111/dom.14104
Abstract: Type 1 diabetes (T1D) is a chronic autoimmune disease leading to progressive loss of pancreatic beta cells. Interferon (IFN)‐α plays a critical role in the crosstalk between pancreatic beta cells and the immune system in… read more here.
Keywords: protection; beta cells; beta; type diabetes ... See more keywords
Gingival Tissue Human Beta-Defensin Levels in Relation to Infection and Inflammation.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of clinical periodontology"
DOI: 10.1111/jcpe.13227
Abstract: AIM To profile gingival tissue levels of human beta-defensin (hBD)-2 and hBD-3 in relation to gingival inflammation, Th17-related cytokine concentrations, Porphyromonas gingivalis counts, and gingipain and total protease activities. MATERIALS AND METHODS Gingival tissue and… read more here.
Keywords: gingival tissue; beta defensin; hbd; inflammation ... See more keywords
Mitogen Synergy: An Emerging Route to Boosting Human Beta Cell Proliferation
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.734597
Abstract: Decreased number and function of beta cells are a key aspect of diabetes mellitus (diabetes), a disease that remains an onerous global health problem. Means of restoring beta cell mass are urgently being sought as… read more here.
Keywords: cell proliferation; beta cells; beta cell; human beta ... See more keywords
Human Beta Defensin 2 Ameliorated Alcohol-Associated Liver Disease in Mice
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.812882
Abstract: Alcohol-associated liver disease (ALD) is a prevalent liver disorder and significant global healthcare burden with limited effective therapeutic options. The gut-liver axis is a critical factor contributing to susceptibility to liver injury due to alcohol… read more here.
Keywords: alcohol associated; beta defensin; liver disease; associated liver ... See more keywords
Inactivation of HIV-1 in Polarized Infant Tonsil Epithelial Cells by Human Beta-Defensins 2 and 3 Tagged with the Protein Transduction Domain of HIV-1 Tat
Sign Up to like & getrecommendations! Published in 2021 at "Viruses"
DOI: 10.3390/v13102043
Abstract: Mother-to-child transmission (MTCT) of HIV-1 may occur during pregnancy, labor, and breastfeeding; however, the molecular mechanism of MTCT of virus remains poorly understood. Infant tonsil mucosal epithelium may sequester HIV-1, serving as a transient reservoir,… read more here.
Keywords: epithelial cells; hiv; protein transduction; beta defensins ... See more keywords