Age-dependent formation of TMEM106B amyloid filaments in human brains.
Sign Up to like & getrecommendations! Published in 2022 at "Nature"
DOI: 10.1038/s41586-022-04650-z
Abstract: Many age-dependent neurodegenerative diseases, like Alzheimer's and Parkinson's, are characterised by abundant inclusions of amyloid filaments. Filamentous inclusions of the proteins tau, amyloid-β (Aβ), α-synuclein and TDP-43 are the most common1,2. Here, we used electron… read more here.
Keywords: tmem106b; age dependent; human brains; filaments human ... See more keywords
BrainEXP: a database featuring with spatiotemporal expression variations and co‐expression organizations in human brains
Sign Up to like & getrecommendations! Published in 2019 at "Bioinformatics"
DOI: 10.1093/bioinformatics/bty576
Abstract: Summary: Gene expression changes over the lifespan and varies among different tissues or cell types. Gene co‐expression also changes by sex, age, different tissues or cell types. However, gene expression under the normal state and… read more here.
Keywords: spatiotemporal expression; gene expression; human brains; expression ... See more keywords
Fukutin regulates tau phosphorylation and synaptic function: Novel properties of fukutin in neurons
Sign Up to like & getrecommendations! Published in 2022 at "Neuropathology"
DOI: 10.1111/neup.12797
Abstract: Fukutin, a product of the causative gene of Fukuyama congenital muscular dystrophy (FCMD), is known to be responsible for basement membrane formation. Patients with FCMD exhibit not only muscular dystrophy but also central nervous system… read more here.
Keywords: human brains; sy5y cells; tau phosphorylation; fukutin ... See more keywords
Cryo-EM structures of amyloid-β 42 filaments from human brains
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.abm7285
Abstract: Description Hi-res view of human Aβ42 filaments Alzheimer’s disease is characterized by a loss of memory and other cognitive functions and the filamentous assembly of Aβ and tau in the brain. The assembly of Aβ… read more here.
Keywords: filaments human; alzheimer disease; type filaments; microscopy ... See more keywords
Protein farnesylation is upregulated in Alzheimer’s human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer’s model mice
Sign Up to like & getrecommendations! Published in 2021 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-021-01231-5
Abstract: The pathogenic mechanisms underlying the development of Alzheimer’s disease (AD) remain elusive and to date there are no effective prevention or treatment for AD. Farnesyltransferase (FT) catalyzes a key posttranslational modification process called farnesylation, in… read more here.
Keywords: farnesyltransferase; protein farnesylation; human brains; mice ... See more keywords
Phosphorylated TDP-43 localizes to chronic cerebral infarctions in human brains.
Sign Up to like & getrecommendations! Published in 2020 at "Histology and histopathology"
DOI: 10.14670/hh-18-235
Abstract: The transactivation response DNA-binding protein of 43 kDa (TDP-43) is a nuclear protein pivotal in RNA processing. Because phosphorylated TDP43 (pTDP-43) has been identified as a component of the ubiquitin-positive and tau-negative inclusions observed in… read more here.
Keywords: cerebral infarctions; human brains; ptdp; chronic cerebral ... See more keywords
Whole-brain comparison of rodent and human brains using spatial transcriptomics
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DOI: 10.7554/elife.79418
Abstract: The ever-increasing use of mouse models in preclinical neuroscience research calls for an improvement in the methods used to translate findings between mouse and human brains. Previously, we showed that the brains of primates can… read more here.
Keywords: similarity; whole brain; brain; mouse human ... See more keywords