New functionalized 6-thienylpyrimidine-5-carbonitriles as antiproliferative agents against human breast cancer cells.
Sign Up to like & getrecommendations! Published in 2021 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202100177
Abstract: 6-Thienylpyrimidine-5-carbonitrile derivatives were synthesized and screened for their in vitro antiproliferative activities against two human breast cancer cell lines in comparison to 5-fluorouracil as a reference. Compounds 2, 3a-c, and 6b evolved as the most… read more here.
Keywords: human breast; new functionalized; thienylpyrimidine; breast cancer ... See more keywords
An aptasensor for rapid and sensitive detection of estrogen receptor alpha in human breast cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.26819
Abstract: The analysis of estrogen receptor (ER) expression in breast carcinomas plays a crucial role in determining the endocrine responsiveness of tumors for systemic adjuvant therapy. Conventionally, the ER levels in breast carcinomas had been detected… read more here.
Keywords: human breast; detection; breast; aptasensor ... See more keywords
CD26 expression is attenuated by TGF‐β and SDF‐1 autocrine signaling on stromal myofibroblasts in human breast cancers
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.2249
Abstract: Human breast carcinoma‐associated fibroblasts (CAFs) increasingly acquire both transforming growth factor‐β (TGF‐β) and stromal cell‐derived factor‐1 (SDF‐1) signaling in an autocrine fashion during tumor progression. Such signaling mediates activated myofibroblastic and tumor‐promoting properties in these… read more here.
Keywords: breast cancers; human breast; expression; cd26 expression ... See more keywords
Proteomics Analysis of Human Breast Milk by Two-Dimensional Polyacrylamide Gel Electrophoresis (2D-PAGE) Coupled with Mass Spectrometry to Assess Breast Cancer Risk.
Sign Up to like & getrecommendations! Published in 2023 at "Electrophoresis"
DOI: 10.1002/elps.202300040
Abstract: Breast Cancer (BC) is one of the most common cancers and one of the most common causes for cancer- related mortality. Discovery of protein biomarkers associated with cancer, is considered as important for early diagnosis… read more here.
Keywords: mass spectrometry; breast; breast milk; milk ... See more keywords
Decreased differentiation capacity and altered expression of extracellular matrix components in irradiation‐mediated senescent human breast adipose‐derived stem cells
Sign Up to like & getrecommendations! Published in 2022 at "IUBMB Life"
DOI: 10.1002/iub.2659
Abstract: Radiotherapy is widely used for the treatment of breast cancer. However, we have shown that ionizing radiation can provoke premature senescence in breast stromal cells. In particular, breast stromal fibroblasts can become senescent after irradiation… read more here.
Keywords: matrix components; extracellular matrix; breast; expression ... See more keywords
Atractylodin induces oxidative stress‐mediated apoptosis and autophagy in human breast cancer MCF‐7 cells through inhibition of the P13K/Akt/mTOR pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23081
Abstract: This study aimed to determine the apoptosis and autophagy‐inducing mechanism of atractylodin in human breast cancer MCF‐7 cells. The molecular mechanism of anticancer activity of atractylodin was confirmed by assessing the levels of reactive oxygen… read more here.
Keywords: mcf; apoptosis autophagy; breast cancer; human breast ... See more keywords
Licochalcone A Suppresses Specificity Protein 1 as a Novel Target in Human Breast Cancer Cells
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26131
Abstract: Licochalcone A (LCA), isolated from the root of Glycyrrhiza inflata, are known to have medicinal effect such as anti‐oxidant, anti‐bacterial, anti‐viral, and anti‐cancer. Though, as a pharmacological mechanism regulator, anti‐cancer studies on LCA were not… read more here.
Keywords: protein; human breast; breast cancer; cancer cells ... See more keywords
Protease‐activated receptor 2 promotes actomyosin dependent transforming microvesicles generation from human breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22891
Abstract: Apart from blood coagulation, coagulation proteases are involved inextricably in cancer progression/propagation via intra/inter‐cellular signaling, mediated predominantly by protease‐activated receptors (PARs). Microvesicles (MVs), a plasma membrane shredded component, has recently been identified as an important… read more here.
Keywords: human breast; breast cancer; generation; protease activated ... See more keywords
Amplification of SOX4 promotes PI3K/Akt signaling in human breast cancer
Sign Up to like & getrecommendations! Published in 2017 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-017-4139-2
Abstract: PurposeThe PI3K/Akt signaling axis contributes to the dysregulation of many dominant features in breast cancer including cell proliferation, survival, metabolism, motility, and genomic instability. While multiple studies have demonstrated that basal-like or triple-negative breast tumors… read more here.
Keywords: human breast; akt signaling; breast; breast cancer ... See more keywords
Propagation of functional estrogen receptor positive normal human breast cells in 3D cultures
Sign Up to like & getrecommendations! Published in 2019 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-019-05229-5
Abstract: PurposeUnderstanding how differentiation, microenvironment, and hormonal milieu influence human breast cell susceptibility to malignant transformation will require the use of physiologically relevant in vitro systems. We sought to develop a 3D culture model that enables… read more here.
Keywords: human breast; estrogen receptor; cells cultures;
Preclinical study of the antitumor effect of sphingosine-1-phosphate receptor 1 antibody (S1PR1-antibody) against human breast cancer cells
Sign Up to like & getrecommendations! Published in 2018 at "Investigational New Drugs"
DOI: 10.1007/s10637-018-0618-5
Abstract: SummarySphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite, which regulates a broad range of physiological and pathophysiological processes. The signaling of S1P via its cell surface receptor S1PR1 has been identified to play an important role… read more here.
Keywords: human breast; antibody; effect; s1pr1 antibody ... See more keywords