Mice with Calr mutations homologous to human CALR mutations only exhibit mild thrombocytosis
Sign Up to like & getrecommendations! Published in 2019 at "Blood Cancer Journal"
DOI: 10.1038/s41408-019-0202-z
Abstract: Calreticulin (CALR) exon 9 frameshift mutations, commonly detected in essential thrombocythemia (ET) and primary myelofibrosis patients, activate signal transducer and activator of transcription (STAT) proteins in the presence of Myeloproliferative Leukemia Virus (MPL) and induce… read more here.
Keywords: mpl; human calr; mild thrombocytosis; mice ... See more keywords
Targeting human CALR‐mutated MPN progenitors with a neoepitope‐directed monoclonal antibody
Sign Up to like & getrecommendations! Published in 2022 at "EMBO Reports"
DOI: 10.15252/embr.202152904
Abstract: Calreticulin (CALR) is recurrently mutated in myelofibrosis via a frameshift that removes an endoplasmic reticulum retention signal, creating a neoepitope potentially targetable by immunotherapeutic approaches. We developed a specific rat monoclonal IgG2α antibody, 4D7, directed… read more here.
Keywords: targeting human; calr; human calr; mutant calr ... See more keywords