An oncospace for human cancers
Sign Up to like & getrecommendations! Published in 2023 at "BioEssays"
DOI: 10.1002/bies.202200215
Abstract: Human cancers comprise an heterogeneous array of diseases with different progression patterns and responses to therapy. However, they all develop within a host context that constrains their natural history. Since it occurs across the diversity… read more here.
Keywords: oncospace human; human cancers; cancer; topology ... See more keywords
Adjuvant chemotherapy with melatonin for targeting human cancers: A review
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27259
Abstract: Melatonin is a multifunctional hormone that has long been known for its antitumoral effects. An advantage of the application of melatonin in cancer therapy is its ability to differentially influence tumors from normal cells. In… read more here.
Keywords: chemotherapy; combination; therapy; human cancers ... See more keywords
The roles of moonlight ribosomal proteins in the development of human cancers
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27722
Abstract: “Moonlighting protein” is a term used to define a single protein with multiple functions and different activities that are not derived from gene fusions, multiple RNA splicing, or the proteolytic activity of promiscuous enzymes. Different… read more here.
Keywords: proteins development; human cancers; ribosomal proteins; roles moonlight ... See more keywords
Epi‐miRNAs: Modern mediators of methylation status in human cancers
Sign Up to like & getrecommendations! Published in 2022 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1735
Abstract: Methylation of the fundamental macromolecules, DNA/RNA, and proteins, is remarkably abundant, evolutionarily conserved, and functionally significant in cellular homeostasis and normal tissue/organism development. Disrupted methylation imprinting is strongly linked to loss of the physiological equilibrium… read more here.
Keywords: mediators methylation; methylation; human cancers; mirnas modern ... See more keywords
Regulation of F-box proteins by noncoding RNAs in human cancers.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2019.09.008
Abstract: F-box proteins (FBPs) are proteins containing an F-box domain and are one of three subunits in SKP1-Cullin1-F-box protein (SCF) E3 ligase complexes. Accumulated evidence has shown that FBP regulates tumorigenesis and the progression of human… read more here.
Keywords: human cancers; box proteins; noncoding rnas; box ... See more keywords
Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy.
Sign Up to like & getrecommendations! Published in 2017 at "DNA repair"
DOI: 10.1016/j.dnarep.2017.06.003
Abstract: The fidelity of DNA replication relies on three error avoidance mechanisms acting in series: nucleotide selectivity of replicative DNA polymerases, exonucleolytic proofreading, and post-replicative DNA mismatch repair (MMR). MMR defects are well known to be… read more here.
Keywords: human cancers; dna; dna polymerase; polymerase ... See more keywords
NORAD, a critical long non-coding RNA in human cancers.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118665
Abstract: The incidence of cancer is growing worldwide, and it is becoming the most common cause of death. Long non-coding RNAs (lncRNAs) are a group of RNA transcripts with a length larger than 200 nucleotides that… read more here.
Keywords: critical long; human cancers; long non; norad critical ... See more keywords
LncRNAs in human cancers: signal from noise.
Sign Up to like & getrecommendations! Published in 2022 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2022.01.006
Abstract: Given the biochemical reaction stochasticity, the mechanisms leading to conservation of biological functions from noise are obscure. Pervasive transcription of nonconserved genomic regions generates lowly expressed cancer-specific long noncoding RNAs (lncRNAs). How such poorly expressed… read more here.
Keywords: cancer; noise; lncrnas human; cancers signal ... See more keywords
Dissection of Cancer Mutational Signatures with Individual Components of Cigarette Smoking.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.3c00021
Abstract: Tobacco smoke delivers a complex mixture of hazardous and potentially hazardous chemicals. Some of these may induce the formation of DNA mutations, which increases the risk of various cancers that display characteristic patterns of accumulated… read more here.
Keywords: dissection cancer; tobacco; human cancers; mutational signatures ... See more keywords
Why are there hotspot mutations in the TP53 gene in human cancers?
Sign Up to like & getrecommendations! Published in 2018 at "Cell Death and Differentiation"
DOI: 10.1038/cdd.2017.180
Abstract: The p53 gene contains homozygous mutations in ~50–60% of human cancers. About 90% of these mutations encode missense mutant proteins that span ~190 different codons localized in the DNA-binding domain of the gene and protein.… read more here.
Keywords: human cancers; dna; hotspot mutations; gene ... See more keywords
The emerging roles of WBP2 oncogene in human cancers
Sign Up to like & getrecommendations! Published in 2020 at "Oncogene"
DOI: 10.1038/s41388-020-1318-0
Abstract: WW domain-binding protein 2 (WBP2) is an emerging oncoprotein. Over the past decade, WBP2 surfaced as a key node connecting key signaling pathways associated with ER/PR, EGFR, PI3K, Hippo, and Wnt in cancer. In addition… read more here.
Keywords: medicine; human cancers; oncogene human; wbp2 oncogene ... See more keywords