Reproducibility of human cardiac phosphorus MRS (31P‐MRS) at 7 T
Sign Up to like & getrecommendations! Published in 2019 at "Nmr in Biomedicine"
DOI: 10.1002/nbm.4095
Abstract: We test the reproducibility of human cardiac phosphorus MRS (31P‐MRS) at ultra‐high field strength (7 T) for the first time. The primary motivation of this work was to assess the reproducibility of a ‘rapid’ 6½… read more here.
Keywords: mrs 31p; reproducibility; reproducibility human; cardiac phosphorus ... See more keywords
Targeting HIF‐α for robust prevascularization of human cardiac organoids
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.3165
Abstract: Prevascularized 3D microtissues have been shown to be an effective cell delivery vehicle for cardiac repair. To this end, our lab has explored the development of self‐organizing, prevascularized human cardiac organoids by coseeding human cardiomyocytes… read more here.
Keywords: cardiac organoids; hif; human cardiac; prevascularization ... See more keywords
Inspiration from heart development: Biomimetic development of functional human cardiac organoids.
Sign Up to like & getrecommendations! Published in 2017 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2017.07.021
Abstract: Recent progress in human organoids has provided 3D tissue systems to model human development, diseases, as well as develop cell delivery systems for regenerative therapies. While direct differentiation of human embryoid bodies holds great promise… read more here.
Keywords: cardiac organoids; heart development; human cardiac; cell ... See more keywords
Investigation of the Molecular Interactions Regulating the Function of Human Cardiac Myosin
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1408
Abstract: Cardiac myosin interacts cyclically with actin in the presence of ATP in the sarcomere to drive heart contraction. Previous fiber studies suggested that the structure and function of myosin in the thick filaments are regulated… read more here.
Keywords: hep hmm; myosin; cardiac myosin; human cardiac ... See more keywords
IL‐2‐induced NF‐&kgr;B phosphorylation upregulates cation nonselective conductance in human cardiac fibroblasts
Sign Up to like & getrecommendations! Published in 2018 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2018.08.040
Abstract: Purpose Studies of negative ionotropic effects of IL‐2 create the basis for possible IL‐2 impact on nonselective conductance (GNS), which potentially makes these effects useful in elucidation of the pathways affected by IL‐2. Materials and… read more here.
Keywords: stim orai; kgr; cardiac fibroblasts; human cardiac ... See more keywords
A Mechanism of Calmodulin Modulation of the Human Cardiac Sodium Channel.
Sign Up to like & getrecommendations! Published in 2018 at "Structure"
DOI: 10.1016/j.str.2018.03.005
Abstract: The function of the human cardiac sodium channel (NaV1.5) is modulated by the Ca2+ sensor calmodulin (CaM), but the underlying mechanism(s) are controversial and poorly defined. CaM has been reported to bind in a Ca2+-dependent… read more here.
Keywords: cardiac sodium; cam; sodium channel; human cardiac ... See more keywords
Mechanism underlying hooked resurgent-like tail currents induced by an insecticide in human cardiac Nav1.5.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2020.115010
Abstract: Voltage-gated sodium channels are responsible not only for the fast upstroke of the action potential, but they also modify cellular excitability via persistent and resurgent currents. Insecticides act via permanently opening sodium channels to immobilize… read more here.
Keywords: resurgent; hooked resurgent; resurgent like; tail currents ... See more keywords
MicroRNA-365 regulates human cardiac action potential duration
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-021-27856-7
Abstract: Abnormalities of ventricular action potential cause malignant cardiac arrhythmias and sudden cardiac death. Here, we aim to identify microRNAs that regulate the human cardiac action potential and ask whether their manipulation allows for therapeutic modulation… read more here.
Keywords: cardiac action; mir 365; action; human cardiac ... See more keywords
CXCL6 is an important paracrine factor in the pro-angiogenic human cardiac progenitor-like cell secretome
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-11976-6
Abstract: Studies in recent years have established that the principal effects in cardiac cell therapy are associated with paracrine/autocrine factors. We combined several complementary techniques to define human cardiac progenitor cell (CPC) secretome constituted by 914… read more here.
Keywords: cxcl6; cpc; cxcl6 important; cardiac progenitor ... See more keywords
Interindividual heterogeneity affects the outcome of human cardiac tissue decellularization
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-00226-5
Abstract: The extracellular matrix (ECM) of engineered human cardiac tissues corresponds to simplistic biomaterials that allow tissue assembly, or animal derived off-the-shelf non-cardiac specific matrices. Decellularized ECM from human cardiac tissue could provide a means to… read more here.
Keywords: decellularization; interindividual heterogeneity; cardiac tissue; tissue ... See more keywords
Galectin-3 down-regulates antioxidant peroxiredoxin-4 in human cardiac fibroblasts: a new pathway to induce cardiac damage.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical science"
DOI: 10.1042/cs20171389
Abstract: Galectin-3 (Gal-3) is increased in heart failure (HF) and promotes cardiac fibrosis and inflammation. We investigated whether Gal-3 modulates oxidative stress in human cardiac fibroblasts, in experimental animal models and in human aortic stenosis (AS).… read more here.
Keywords: gal; prx; cardiac fibroblasts; human cardiac ... See more keywords