Characterisation and immunosuppressive activity of human cartilage-derived mesenchymal stem cells
Sign Up to like & getrecommendations! Published in 2017 at "Cytotechnology"
DOI: 10.1007/s10616-017-0182-4
Abstract: Mesenchymal stem cells (MSCs) exert potent immuno-regulatory activities on various immune cells and also differentiate into various mesodermal lineages besides retaining a distinct self-renewal ability. Such exclusive characteristics had enabled MSCs to be recognised as… read more here.
Keywords: human cartilage; mscs; stem cells; cartilage ... See more keywords
A tool for evaluating novel osteoarthritis therapies using multivariate analyses of human cartilage-synovium explant co-culture.
Sign Up to like & getrecommendations! Published in 2021 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2021.09.007
Abstract: OBJECTIVE There is a need to incorporate multiple tissues into in vitro OA models to evaluate novel therapeutics. This approach is limited by inherent donor variability. We present an optimized research tool: a human OA… read more here.
Keywords: synovium; tool; cartilage synovium; human cartilage ... See more keywords
Deciphering pathological remodelling of the human cartilage extracellular matrix in osteoarthritis at the supramolecular level.
Sign Up to like & getrecommendations! Published in 2022 at "Nanoscale"
DOI: 10.1039/d2nr00474g
Abstract: The extracellular matrix (ECM) of articular cartilage is a three-dimensional network mainly constituted of entangled collagen fibrils and interfibrillar aggrecan aggregates. During the development of osteoarthritis (OA), the most common musculoskeletal disorder, the ECM is… read more here.
Keywords: ecm; extracellular matrix; pathological remodelling; human cartilage ... See more keywords
Human Cartilage Engineering in an In Vitro Repair Model Using Collagen Scaffolds and Mesenchymal Stromal Cells
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Medical Sciences"
DOI: 10.7150/ijms.19835
Abstract: The purpose of this study was to investigate cartilage repair of in vitro lesion models using human bone marrow mesenchymal stromal cells (hBMSCs) with different collagen (Col) scaffolds. Lesions were made in human cartilage biopsies.… read more here.
Keywords: collagen; mesenchymal stromal; human cartilage; col ... See more keywords
Development of human cartilage circadian rhythm in a stem cell-chondrogenesis model
Sign Up to like & getrecommendations! Published in 2022 at "Theranostics"
DOI: 10.7150/thno.70893
Abstract: The circadian clock in murine articular cartilage is a critical temporal regulatory mechanism for tissue homeostasis and osteoarthritis. However, translation of these findings into humans has been hampered by the difficulty in obtaining circadian time… read more here.
Keywords: human cartilage; cartilage; model; differentiation ... See more keywords