Human Cathelicidin Inhibits SARS-CoV-2 Infection: Killing Two Birds with One Stone
Sign Up to like & getrecommendations! Published in 2021 at "ACS Infectious Diseases"
DOI: 10.1021/acsinfecdis.1c00096
Abstract: SARS-CoV-2 infection begins with the association of its spike 1 (S1) protein with host angiotensin-converting enzyme-2 (ACE2). Targeting the interaction between S1 and ACE2 is a practical strategy against SARS-CoV-2 infection. Herein, we show encouraging… read more here.
Keywords: infection; ace2; human cathelicidin; sars cov ... See more keywords
The structure of the antimicrobial human cathelicidin LL-37 shows oligomerization and channel formation in the presence of membrane mimics
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DOI: 10.1038/s41598-020-74401-5
Abstract: The human cathelicidin LL-37 serves a critical role in the innate immune system defending bacterial infections. LL-37 can interact with molecules of the cell wall and perforate cytoplasmic membranes resulting in bacterial cell death. To… read more here.
Keywords: presence; human cathelicidin; structure; cell ... See more keywords
Design, synthesis, and characterization of non-hemolytic antimicrobial peptides related to human cathelicidin LL-37
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DOI: 10.1039/d3ra02473c
Abstract: We designed and synthesised the N-terminally labeled cationic and hydrophobic peptides, i.e., FFKKSKEKIGKEFKKIVQKI (P1) and FRRSRERIGREFRRIVQRI (P2) related to the human cathelicidin LL-37 peptide. The integrity and molecular weight of the peptides were confirmed by… read more here.
Keywords: design synthesis; related human; synthesis characterization; non hemolytic ... See more keywords
The collectin SP-A and its trimeric recombinant fragment protect alveolar epithelial cells from the cytotoxic and proinflammatory effects of human cathelicidin in vitro
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.994328
Abstract: Human cathelicidin (LL-37) is a defense peptide with antimicrobial activity against various pathogens. However, LL-37 can also trigger tissue injury by binding to host cell membranes. The cytotoxic effects of LL-37 may be especially relevant… read more here.
Keywords: recombinant fragment; trimeric recombinant; rfhsp; human cathelicidin ... See more keywords