18F-labeled anti-human CD20 cys-diabody for same-day immunoPET in a model of aggressive B cell lymphoma in human CD20 transgenic mice
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-018-4214-x
Abstract: PurposeMetabolic imaging using [18F]FDG is the current standard for clinical PET; however, some malignancies (e.g., indolent lymphomas) show low avidity for FDG. The majority of B cell lymphomas express CD20, making it a valuable target… read more here.
Keywords: pet; cell; transgenic mice; cd20 ... See more keywords
Designing of a Functional Chimeric Protein for Production of Nanobodies Against Human CD20: Molecular Dynamics Simulation and In Vitro Verification
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DOI: 10.1007/s10989-018-9791-9
Abstract: One major issue in cancer immunotherapy is the large size of mAbs (150 kDa) which usually causes limitation in tumor penetration. Camel nanobodies ( read more here.
Keywords: protein; chimeric protein; molecular dynamics; dynamics simulation ... See more keywords
Binding mechanisms of therapeutic antibodies to human CD20
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DOI: 10.1126/science.abb8008
Abstract: Strength in numbers Human cluster of differentiation 20 (CD20) is expressed on malignant B cells and is the target of therapeutic antibodies used in cancer immunotherapy. Kumar et al. now present structures that explain why… read more here.
Keywords: therapeutic antibodies; type antibodies; generation; type ... See more keywords
Anti-drug Antibodies Against a Novel Humanized Anti-CD20 Antibody Impair Its Therapeutic Effect on Primary Biliary Cholangitis in Human CD20- and FcγR-Expressing Mice
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.02534
Abstract: There is considerable interest in expanding B cell-targeted therapies in human autoimmune diseases. However, clinical trials in human primary biliary cholangitis (PBC) using a chimeric antibody against human CD20 (hCD20) have showed limited efficacy. Two… read more here.
Keywords: primary biliary; anti drug; antibody; cd20 ... See more keywords