Linear assembly of a human centromere on the Y chromosome
Sign Up to like & getrecommendations! Published in 2018 at "Nature Biotechnology"
DOI: 10.1038/nbt.4109
Abstract: The human genome reference sequence remains incomplete owing to the challenge of assembling long tracts of near-identical tandem repeats in centromeres. We implemented a nanopore sequencing strategy to generate high-quality reads that span hundreds of… read more here.
Keywords: human centromere; linear assembly; centromere chromosome; assembly human ... See more keywords
Visualization of the three-dimensional structure of the human centromere in mitotic chromosomes by super-resolution microscopy.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e22-08-0332
Abstract: The human centromere comprises large arrays of repetitive alpha-satellite DNA at the primary constriction of mitotic chromosomes. In addition, centromeres are epigenetically specified by the centromere-specific histone H3 variant CENP-A that supports kinetochore assembly to… read more here.
Keywords: microscopy; mitotic chromosomes; human centromere; satellite dna ... See more keywords