Evolutionary innovations of human cerebral cortex viewed through the lens of high‐throughput sequencing
Sign Up to like & getrecommendations! Published in 2022 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22893
Abstract: Humans had acquired a tremendously enlarged cerebral cortex containing a huge quantity and variety of cells during evolution. Such evolutionary uniqueness offers a neural basis of our cognitive innovation and human‐specific features of neurodevelopmental and… read more here.
Keywords: evolutionary innovations; cerebral cortex; high throughput; cortex ... See more keywords
Glioblastoma Model Using Human Cerebral Organoids
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.03.105
Abstract: SUMMARY We have developed a cancer model of gliomas in human cerebral organoids that allows direct observation of tumor initiation as well as continuous microscopic observations. We used CRISPR/Cas9 technology to target an HRasG12V-IRES-tdTomato construct… read more here.
Keywords: glioblastoma model; model using; cerebral organoids; human cerebral ... See more keywords
Exploring the human cerebral cortex using confocal microscopy.
Sign Up to like & getrecommendations! Published in 2021 at "Progress in biophysics and molecular biology"
DOI: 10.1016/j.pbiomolbio.2021.09.001
Abstract: Cover-all mapping of the distribution of neurons in the human brain would have a significant impact on the deep understanding of brain function. Therefore, complete knowledge of the structural organization of different human brain regions… read more here.
Keywords: microscopy; cerebral cortex; human brain; human cerebral ... See more keywords
Induction of Expansion and Folding in Human Cerebral Organoids.
Sign Up to like & getrecommendations! Published in 2017 at "Cell stem cell"
DOI: 10.1016/j.stem.2016.11.017
Abstract: An expansion of the cerebral neocortex is thought to be the foundation for the unique intellectual abilities of humans. It has been suggested that an increase in the proliferative potential of neural progenitors (NPs) underlies… read more here.
Keywords: expansion folding; folding human; expansion; induction expansion ... See more keywords
Glial cell diversity and methamphetamine-induced neuroinflammation in human cerebral organoids
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Psychiatry"
DOI: 10.1038/s41380-020-0676-x
Abstract: Methamphetamine (METH) is a potent stimulant that induces a euphoric state but also causes cognitive impairment, neurotoxicity and neurodevelopmental deficits. Yet, the molecular mechanisms by which METH causes neurodevelopmental defects have remained elusive. Here we… read more here.
Keywords: methamphetamine; induced neuroinflammation; cerebral organoids; human cerebral ... See more keywords
Consciousness in a Rotor? Science and Ethics of Potentially Conscious Human Cerebral Organoids
Sign Up to like & getrecommendations! Published in 2023 at "AJOB Neuroscience"
DOI: 10.1080/21507740.2023.2173329
Abstract: Abstract Human cerebral organoids are three-dimensional biological cultures grown in the laboratory to mimic as closely as possible the cellular composition, structure, and function of the corresponding organ, the brain. For now, cerebral organoids lack… read more here.
Keywords: potentially conscious; brain; cerebral organoids; human cerebral ... See more keywords
Regulating Possibly Sentient Human Cerebral Organoids
Sign Up to like & getrecommendations! Published in 2023 at "AJOB Neuroscience"
DOI: 10.1080/21507740.2023.2188293
Abstract: Due to their contested ethical and legal status, human cerebral organoids (HCOs) have become the subject of one of the most rapidly expanding debates in the recent bioethics literature. There is no doubt that their… read more here.
Keywords: regulating possibly; possibly sentient; cerebral organoids; human cerebral ... See more keywords
A Teleological Approach to the Ontological Status of Human Cerebral Organoids
Sign Up to like & getrecommendations! Published in 2023 at "AJOB Neuroscience"
DOI: 10.1080/21507740.2023.2188304
Abstract: Cova, F., M. Gaillard, and F. Kammerer. 2021. Is the phenomenological overflow argument really supported by subjective reports? Mind & Language 36:422–50. doi:10. 1111/mila.12292. Diner, S. under revision. Similarity-based views in anticipatory ethics: From consciousness… read more here.
Keywords: approach ontological; human cerebral; ajob neuroscience; cerebral organoids ... See more keywords
Human Cerebral Organoids: Implications of Ontological considerations
Sign Up to like & getrecommendations! Published in 2023 at "AJOB Neuroscience"
DOI: 10.1080/21507740.2023.2188310
Abstract: The article “ Consciousness in a Bioreactor? Science and Ethics of Potentially Conscious Human Cerebral Organoids ” (Zillo and Lavazza 2023) presents a thoughtful discussion on the potential ethical implications of Human Cerebral Organoids (HCOs).… read more here.
Keywords: organoids implications; implications ontological; cerebral organoids; human cerebral ... See more keywords
Label-free three-photon imaging of intact human cerebral organoids for tracking early events in brain development and deficits in Rett syndrome
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.02.28.482282
Abstract: Human cerebral organoids are unique in their development of progenitor-rich zones akin to ventricular zones from which neuronal progenitors differentiate and migrate radially. Analyses of cerebral organoids thus far have been performed in sectioned tissue… read more here.
Keywords: label free; three photon; development; cerebral organoids ... See more keywords
Sporadic Creutzfeldt-Jakob disease prion infection of human cerebral organoids
Sign Up to like & getrecommendations! Published in 2019 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-019-0742-2
Abstract: For the transmissible, neurogenerative family of prion diseases, few human models of infection exist and none represent structured neuronal tissue. Human cerebral organoids are self-organizing, three-dimensional brain tissues that can be grown from induced pluripotent… read more here.
Keywords: sporadic creutzfeldt; prion; prion infection; disease ... See more keywords